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4mwi

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'''Unreleased structure'''
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{{STRUCTURE_4mwi| PDB=4mwi | SCENE= }}
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===Crystal structure of the human MLKL pseudokinase domain===
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{{ABSTRACT_PUBMED_24219132}}
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The entry 4mwi is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MLKL_HUMAN MLKL_HUMAN]] Required for the execution of programmed necrosis.<ref>PMID:22265414</ref>
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Authors: Czabotar, P.E., Murphy, J.M.
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==About this Structure==
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[[4mwi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MWI OCA].
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Description: Crystal structure of the human MLKL pseudokinase domain
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==Reference==
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<ref group="xtra">PMID:024219132</ref><references group="xtra"/><references/>
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[[Category: Czabotar, P E.]]
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[[Category: Murphy, J M.]]
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[[Category: Necroptosis]]
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[[Category: Pseudokinase]]
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[[Category: Transferase]]

Revision as of 07:23, 4 December 2013

Template:STRUCTURE 4mwi

Contents

Crystal structure of the human MLKL pseudokinase domain

Template:ABSTRACT PUBMED 24219132

Function

[MLKL_HUMAN] Required for the execution of programmed necrosis.[1]

About this Structure

4mwi is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE. Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem J. 2013 Nov 13. PMID:24219132 doi:http://dx.doi.org/10.1042/BJ20131270
  1. ↑ Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012 Jan 20;148(1-2):228-43. doi: 10.1016/j.cell.2011.11.030. PMID:22265414 doi:http://dx.doi.org/10.1016/j.cell.2011.11.030

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