4k09
From Proteopedia
(Difference between revisions)
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===Crystal structure of BbTX-II from Bothrops brazili venom=== | ===Crystal structure of BbTX-II from Bothrops brazili venom=== | ||
{{ABSTRACT_PUBMED_24145104}} | {{ABSTRACT_PUBMED_24145104}} | ||
| - | |||
| - | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/PA2B1_BOTJR PA2B1_BOTJR]] Snake venom phospholipase A2 homolog that lacks enzymatic activity. In vivo, induces muscle necrosis, accompanied by polymorphonuclear cell infiltration, and edema in the mouse paw. Damages artificial and myoblast membranes by a calcium-independent mechanism. Has bactericidal activity.<ref>PMID:3176051</ref> <ref>PMID:11018293</ref> <ref>PMID:11829743</ref> <ref>PMID:12079495</ref> <ref>PMID:17346668</ref> <ref>PMID:18160090</ref> <ref>PMID:17157889</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4k09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4k09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_brazili Bothrops brazili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K09 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024145104</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024145104</ref><references group="xtra"/><references/> | ||
| - | [[Category: Bothrops | + | [[Category: Bothrops brazili]] |
[[Category: Borges, R J.]] | [[Category: Borges, R J.]] | ||
[[Category: Comparetti, E J.]] | [[Category: Comparetti, E J.]] | ||
Revision as of 08:48, 27 November 2013
Crystal structure of BbTX-II from Bothrops brazili venom
Template:ABSTRACT PUBMED 24145104
About this Structure
4k09 is a 2 chain structure with sequence from Bothrops brazili. Full crystallographic information is available from OCA.
Reference
- Fernandes CA, Comparetti EJ, Borges RJ, Huancahuire-Vega S, Ponce-Soto LA, Marangoni S, Soares AM, Fontes MR. Structural bases for a complete myotoxic mechanism: Crystal structures of two non-catalytic phospholipases A-like from Bothrops brazili venom. Biochim Biophys Acta. 2013 Oct 18;1834(12):2772-2781. doi:, 10.1016/j.bbapap.2013.10.009. PMID:24145104 doi:http://dx.doi.org/10.1016/j.bbapap.2013.10.009
