2qdz
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2qdz.jpg|left|200px]] | + | [[Image:2qdz.jpg|left|200px]] |
| - | + | ||
| - | '''Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family''' | + | {{Structure |
| + | |PDB= 2qdz |SIZE=350|CAPTION= <scene name='initialview01'>2qdz</scene>, resolution 3.15Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= fhaC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=520 Bordetella pertussis]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2QDZ is a [ | + | 2QDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDZ OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:[http:// | + | Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702945 17702945] |
[[Category: Bordetella pertussis]] | [[Category: Bordetella pertussis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 21: | Line 30: | ||
[[Category: protein transport]] | [[Category: protein transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:24:51 2008'' |
Revision as of 16:24, 20 March 2008
| |||||||
| , resolution 3.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | fhaC (Bordetella pertussis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family
Overview
In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB) superfamily are essential components of protein transport machineries. The TpsB transporter FhaC mediates the secretion of Bordetella pertussis filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of FhaC. The transporter comprises a 16-stranded beta barrel that is occluded by an N-terminal alpha helix and an extracellular loop and a periplasmic module composed of two aligned polypeptide-transport-associated (POTRA) domains. Functional data reveal that FHA binds to the POTRA 1 domain via its N-terminal domain and likely translocates the adhesin-repeated motifs in an extended hairpin conformation, with folding occurring at the cell surface. General features of the mechanism obtained here are likely to apply throughout the superfamily.
About this Structure
2QDZ is a Single protein structure of sequence from Bordetella pertussis. Full crystallographic information is available from OCA.
Reference
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:17702945
Page seeded by OCA on Thu Mar 20 18:24:51 2008
