2qf5
From Proteopedia
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| - | [[Image:2qf5.jpg|left|200px]] | + | [[Image:2qf5.jpg|left|200px]] |
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| - | '''High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)''' | + | {{Structure |
| + | |PDB= 2qf5 |SIZE=350|CAPTION= <scene name='initialview01'>2qf5</scene>, resolution 2.23Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= mreC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 Streptococcus pneumoniae R6]) | ||
| + | }} | ||
| + | |||
| + | '''High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2QF5 is a [ | + | 2QF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF5 OCA]. |
==Reference== | ==Reference== | ||
| - | High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:[http:// | + | High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17707860 17707860] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pneumoniae r6]] | [[Category: Streptococcus pneumoniae r6]] | ||
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[[Category: structural protein]] | [[Category: structural protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:25:12 2008'' |
Revision as of 16:25, 20 March 2008
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| , resolution 2.23Å | |||||||
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| Gene: | mreC (Streptococcus pneumoniae R6) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)
Overview
Bacterial cell shape is dictated by the cell wall, a plastic structure that must adapt to growth and division whilst retaining its function as a selectively permeable barrier. The modulation of cell wall structure is achieved by a variety of enzymatic functions, all of which must be spatially regulated in a precise manner. The membrane-spanning essential protein MreC has been identified as the central hub in this process, linking the bacterial cytoskeleton to a variety of cell wall-modifying enzymes. Additionally, MreC can form filaments, believed to run perpendicularly to the membrane. We present here the 1.2 A resolution crystal structure of the major periplasmic domain of Streptococcus pneumoniae MreC. The protein shows a novel arrangement of two barrel-shaped domains, one of which shows homology to a known protein oligomerization motif, with the other resembling a catalytic domain from a bacterial protease. We discuss the implications of these results for MreC function, and detail the structural features of the molecule that may be responsible for the binding of partner proteins.
About this Structure
2QF5 is a Single protein structure of sequence from Streptococcus pneumoniae r6. Full crystallographic information is available from OCA.
Reference
High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:17707860
Page seeded by OCA on Thu Mar 20 18:25:12 2008
