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4nfn

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4nfn| PDB=4nfn | SCENE= }}
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===Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol===
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The entry 4nfn is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TTBK1_HUMAN TTBK1_HUMAN]] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.<ref>PMID:16923168</ref>
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Authors: Sheriff, S.
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==About this Structure==
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[[4nfn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFN OCA].
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Description: Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Sheriff, S.]]
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[[Category: Phosphotransferase]]
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[[Category: Protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 11:37, 5 February 2014

Template:STRUCTURE 4nfn

Contents

Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol

Function

[TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.[1]

About this Structure

4nfn is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep;98(5):1573-84. PMID:16923168 doi:JNC4059

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OCA

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