4l63

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{{STRUCTURE_4l63| PDB=4l63 | SCENE= }}
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==Apo form of AB5 holotoxin==
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===Apo form of AB5 holotoxin===
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<StructureSection load='4l63' size='340' side='right' caption='[[4l63]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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{{ABSTRACT_PUBMED_24095060}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l63]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L63 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ecxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), ecxB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l63 RCSB], [http://www.ebi.ac.uk/pdbsum/4l63 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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AB5 toxins are composed of an enzymatic A subunit that disrupts cellular function associated with a pentameric B subunit required for host cell invasion. EcxAB is an AB5 toxin isolated from clinical strains of Escherichia coli classified as part of the cholera family due to B subunit homology. Cholera-group toxins have catalytic ADP-ribosyltransferases as their A subunits, so it was surprising that EcxA did not. We confirmed that EcxAB self-associates as a functional toxin and obtained its structure. EcxAB is a prototypical member of a hybrid AB5 toxin family containing metzincin-type metalloproteases as their active A subunit paired to a cholera-like B subunit. Furthermore, EcxA is distinct from previously characterized proteases and thus founds an AB5-associated metzincin family that we term the toxilysins. EcxAB provides the first observation of conserved B subunit usage across different AB5 toxin families and provides evidence that the intersubunit interface of these toxins is far more permissive than previously supposed.
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==About this Structure==
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EcxAB Is a Founding Member of a New Family of Metalloprotease AB Toxins with a Hybrid Cholera-like B Subunit.,Ng NM, Littler DR, Paton AW, Le Nours J, Rossjohn J, Paton JC, Beddoe T Structure. 2013 Oct 1. pii: S0969-2126(13)00345-6. doi:, 10.1016/j.str.2013.08.024. PMID:24095060<ref>PMID:24095060</ref>
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[[4l63]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L63 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024095060</ref><references group="xtra"/><references/>
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</div>
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[[Category: Beddoe, T.]]
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== References ==
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[[Category: Littler, D R.]]
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<references/>
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[[Category: Ng, N M.]]
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__TOC__
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[[Category: Rossjohn, J.]]
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</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Beddoe, T]]
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[[Category: Littler, D R]]
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[[Category: Ng, N M]]
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[[Category: Rossjohn, J]]
[[Category: Ab5 toxin]]
[[Category: Ab5 toxin]]
[[Category: Cholera-like toxin]]
[[Category: Cholera-like toxin]]

Revision as of 16:45, 21 December 2014

Apo form of AB5 holotoxin

4l63, resolution 1.80Å

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