4nb6
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4nb6| PDB=4nb6 | SCENE= }} | {{STRUCTURE_4nb6| PDB=4nb6 | SCENE= }} | ||
===Crystal structure of the ligand binding domain of RORC with T0901317=== | ===Crystal structure of the ligand binding domain of RORC with T0901317=== | ||
| + | {{ABSTRACT_PUBMED_24239186}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4nb6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB6 OCA]. | + | [[4nb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB6 OCA]. |
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024239186</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Hymowitz, S G.]] | [[Category: Hymowitz, S G.]] | ||
[[Category: Leon, G Boenig-de.]] | [[Category: Leon, G Boenig-de.]] | ||
Revision as of 08:27, 18 December 2013
Contents |
Crystal structure of the ligand binding domain of RORC with T0901317
Template:ABSTRACT PUBMED 24239186
Function
[RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
About this Structure
4nb6 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Fauber BP, de Leon Boenig G, Burton B, Eidenschenk C, Everett C, Gobbi A, Hymowitz SG, Johnson AR, Liimatta M, Lockey P, Norman M, Ouyang W, Rene O, Wong H. Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6604-9. doi: 10.1016/j.bmcl.2013.10.054., Epub 2013 Nov 4. PMID:24239186 doi:http://dx.doi.org/10.1016/j.bmcl.2013.10.054
