Histone methyltransferase

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[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
[[2lv9]] - hKHMT Mll5 residues 109-188 - NMR<br />
[[2lv9]] - hKHMT Mll5 residues 109-188 - NMR<br />
 +
[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br />
 +
[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br />
 +
[[3lqh]] - hKHMT Mll Phd bromodomain<br />
 +
[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br />
 +
[[3bo5]] – hKHMT Setmar methyltransferase domain <br />
 +
[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
 +
[[3dlm]] - hKHMT Setmdb1 Tudor domain <br />
[[3n71]] - hKHMT Smyd1<br />
[[3n71]] - hKHMT Smyd1<br />
 +
[[3rsn]], [[3s32]] – hKHMT Ash2 N terminal<br />
 +
[[3toj]] – hKHMT Ash2 Spry domain<br />
 +
[[4ijd]] – hKHMT Prdm9<br />
[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
-
[[1u2z]] – yKHMT C terminal
+
[[1u2z]] – yKHMT C terminal<br />
 +
[[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br />
 +
[[2l7p]] – AtKHMT Suvr4 SET31 - NMR<br />
-
===Histone-lysine N-methyltransferase complexes===
+
===Histone-lysine N-methyltransferase binary complexes===
 +
[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br />
 +
[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br />
 +
[[3qow]] – hKHMT + SAM <br />
 +
[[4fmu]] – hKHMT SETD2 + inhibitor <br />
 +
[[4h12]] – hKHMT SETD2 + SAH <br />
 +
[[3smt]] – hKHMT SETD3 + SAM <br />
 +
[[4bup]], [[3ooi]] – hKHMT SET domain + SAM <br />
 +
[[3qox]], [[3sx0]] – hKHMT + SAH <br />
 +
[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
 +
[[2w5y]] – hKHMT Hrx methyltransferase domain +_SAH <br />
 +
[[3lqi]], [[3lqj]] - hKHMT Mll Phd bromodomain + H3 peptide<br />
 +
[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br />
 +
[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br />
 +
[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
 +
[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
 +
[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
[[3rib]] – hKHMT Smyd2 + SAH<br />
[[3rib]] – hKHMT Smyd2 + SAH<br />
-
[[1o9s]] - hKHMT SET7/9 Set domain + SAH + H3 peptide<br />
 
-
[[2bqz]] - hKHMT SET7 Set domain + SAH + H4 peptide<br />
 
[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br />
[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br />
 +
[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br />
 +
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
 +
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
 +
[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
 +
 +
===Histone-lysine N-methyltransferase ternary complex===
 +
 +
[[2w5z]] – hKHMT Hrx methyltransferase domain +_SAH + histone peptide<br />
 +
[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
 +
[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
 +
[[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br />
 +
[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
 +
[[4j7i]], [[4j83]], [[4j8o]] - hKHMT SETD7 + SAH + TFIID peptide<br />
 +
[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
 +
[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br />
[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br />
[[2f69]], [[3m53]] - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide<br />
[[2f69]], [[3m53]] - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide<br />
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[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br />
[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br />
[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br />
[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br />
-
[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br />
 
-
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
 
[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br />
[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br />
-
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor
+
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br />
-
 
+
[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
-
[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide
+
[[1zkk]] - hKHMT + SAH + H4 peptide <br />
-
 
+
[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
-
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
+
[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
-
[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
+
[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
[[2g46]] – PvKHMT + SAH + H3 peptide<br />
[[2g46]] – PvKHMT + SAH + H3 peptide<br />
[[4au7]] - KHMT + SAH + H4 peptide - mouse<br />
[[4au7]] - KHMT + SAH + H4 peptide - mouse<br />
 +
[[3rib]] – hKHMT Smyd2 + SAH<br />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:15, 17 March 2014

Template:STRUCTURE 3s7j

Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT.

Contents

3D Structures of histone methyltransferase

Updated on 17-March-2014

1nw3 – hHMT DOT1L – human

2igq – hHMT-1 C terminal

Histone-lysine N-methyltransferase

2j8a – KHMT SET1 RRM domain – yeast

3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT SET7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
2kyu - hKHMT Mll Phd3 finger – NMR
4gnd - hKHMT Nsd3 Phd5-C5HCH
3lqh - hKHMT Mll Phd bromodomain
3b7b - hKHMT ankyrin repeat domains 2-7
3bo5 – hKHMT Setmar methyltransferase domain
3k9j, 3k9k – hKHMT Setmar transposable domain (mutant)
3dlm - hKHMT Setmdb1 Tudor domain
3n71 - hKHMT Smyd1
3rsn, 3s32 – hKHMT Ash2 N terminal
3toj – hKHMT Ash2 Spry domain
4ijd – hKHMT Prdm9
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal
2l7p – AtKHMT Ashh2 CW domain – Arabidopsis thaliana - NMR
2l7p – AtKHMT Suvr4 SET31 - NMR

Histone-lysine N-methyltransferase binary complexes

2kkf – hKHMT Hrx CxxC domain +_DNA – NMR
3q0b, 3q0c, 3q0d, 3q0f – hKHMT SRA domain +_DNA
3qow – hKHMT + SAM
4fmu – hKHMT SETD2 + inhibitor
4h12 – hKHMT SETD2 + SAH
3smt – hKHMT SETD3 + SAM
4bup, 3ooi – hKHMT SET domain + SAM
3qox, 3sx0 – hKHMT + SAH
3sr4, 3uwp, 4ek9, 4ekg, 4eki, 4eqz, 4er0, 4er3, 4er5, 4er6, 4er7, 4hra - hKHMT catalytic domain + inhibitor
2w5y – hKHMT Hrx methyltransferase domain +_SAH
3lqi, 3lqj - hKHMT Mll Phd bromodomain + H3 peptide
3f2k – hKHMT Setmar SET domain + LYFA peptide
3sw9, 3swc – hKHMT SET domain + peptide
4gne, 4gnf, 4gng - hKHMT Nsd3 Phd5-C5HCH + H3 peptide
3b95 - hKHMT ankyrin repeat domain + H3 peptide
3lqi, 3lqj - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide
3rib – hKHMT Smyd2 + SAH
1mt6 - hKHMT SET7/9 residues 58-337 + SAH
1n6a – hKHMT SET7/9 SET domain + SAM
1n6c – hKHMT SET7/9 residues 70-366 + SAM
3cbp - hKHMT SET7/9 SET domain + sinefungin
3vuz, 3vv0 - hKHMT SET7/9 SET domain + deoxyadenosine derivative
3s7j, 3tg4 - hKHMT Smyd2 + SAM
4l58 - hKHMT PHD-type zinc finger domain + H3 peptide

Histone-lysine N-methyltransferase ternary complex

2w5z – hKHMT Hrx methyltransferase domain +_SAH + histone peptide
1o9s - hKHMT SET7/9 SET domain + SAH + H3 peptide
2bqz - hKHMT SET7 SET domain + SAH + H4 peptide
3f9w, 3f9x, 3f9y, 3f9z - hKHMT SETD8 SET domain + SAH + H4 peptide
4ij8 - hKHMT SETD8 + SAM + H3 peptide
4j7i, 4j83, 4j8o - hKHMT SETD7 + SAH + TFIID peptide
3fpd, 3k5k, 3mo0, 3mo2, 3mo5, 3rjw, 4nvq - hKHMT SET domain + SAH + inhibitor
2rfi, 3hna - hKHMT H3K9 catalytic domain + SAH + H3 peptide
1xqh - hKHMT SET7/9 SET domain + SAH + p53 peptide
2f69, 3m53 - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide
3m54, 3m55, 3m56, 3m57, 3m58, 3m59, 3m5a - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide
3cbm - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide
4e47, 4jds, 4jlg - hKHMT SET7/9 SET domain + SAM + inhibitor
3cbo - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide
3os5 - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide
3qxy, 3rc0 - hKHMT SETD6 SET domain + p65 peptide + SAM
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
1zkk - hKHMT + SAH + H4 peptide
4c1q - hKHMT SET domain + SAH + H3 peptide
4i51 - hKHMT (mutant) + SAH + H3 peptide
1peg - NcKHMT Dim-5 + SAH + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide
4au7 - KHMT + SAH + H4 peptide - mouse
3rib – hKHMT Smyd2 + SAH

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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