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4cge

From Proteopedia

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m (Protected "4cge" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4cge| PDB=4cge | SCENE= }}
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===Bacterial secreted hydrolase A===
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{{ABSTRACT_PUBMED_24452911}}
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The entry 4cge is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RPFE_MYCTU RPFE_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref>
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Authors: Mavrici, D., Prigozhin, D.M., Alber, T.
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==About this Structure==
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[[4cge]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGE OCA].
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Description: Bacterial secreted hydrolase A
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==Reference==
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<ref group="xtra">PMID:024452911</ref><references group="xtra"/><references/>
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[[Category: Alber, T.]]
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[[Category: Mavrici, D.]]
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[[Category: Prigozhin, D M.]]
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[[Category: Hydrolase]]
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[[Category: Secreted protein]]

Revision as of 11:07, 5 February 2014

Template:STRUCTURE 4cge

Contents

Bacterial secreted hydrolase A

Template:ABSTRACT PUBMED 24452911

Function

[RPFE_MYCTU] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.[1] Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.[2]

About this Structure

4cge is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mavrici D, Prigozhin DM, Alber T. Mycobacterium tuberculosis RpfE crystal structure reveals a positively charged catalytic cleft. Protein Sci. 2014 Jan 22. doi: 10.1002/pro.2431. PMID:24452911 doi:http://dx.doi.org/10.1002/pro.2431
  1. ↑ Mukamolova GV, Turapov OA, Young DI, Kaprelyants AS, Kell DB, Young M. A family of autocrine growth factors in Mycobacterium tuberculosis. Mol Microbiol. 2002 Nov;46(3):623-35. PMID:12410821
  2. ↑ Mukamolova GV, Turapov OA, Young DI, Kaprelyants AS, Kell DB, Young M. A family of autocrine growth factors in Mycobacterium tuberculosis. Mol Microbiol. 2002 Nov;46(3):623-35. PMID:12410821

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