4ifh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ifh| PDB=4ifh | SCENE= }}
 +
===Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619===
-
The entry 4ifh is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
-
Authors: Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.
+
==About this Structure==
 +
[[4ifh]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gse 4gse]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFH OCA].
-
Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Insulysin]]
 +
[[Category: Deprez, B.]]
 +
[[Category: Deprez, R.]]
 +
[[Category: Guo, Q.]]
 +
[[Category: Liang, W G.]]
 +
[[Category: Tang, W.]]
 +
[[Category: Hydrolase-hydrolase inhibitor complex]]
 +
[[Category: Insulin degrading enzyme]]

Revision as of 10:16, 18 December 2013

Template:STRUCTURE 4ifh

Contents

Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619

Function

[IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.[1] [2] [3]

About this Structure

4ifh is a 2 chain structure. This structure supersedes the now removed PDB entry 4gse. Full crystallographic information is available from OCA.

Reference

  1. ↑ Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. PMID:10684867
  2. ↑ Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531 doi:10.1074/jbc.M701590200
  3. ↑ Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ. Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme. Biochemistry. 2008 Nov 6. PMID:18986166 doi:10.1021/bi801192h

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ifh"
Personal tools