4nf9

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'''Unreleased structure'''
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{{STRUCTURE_4nf9| PDB=4nf9 | SCENE= }}
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===Structure of the Knl1/Nsl1 complex===
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{{ABSTRACT_PUBMED_24530301}}
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The entry 4nf9 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/CASC5_HUMAN CASC5_HUMAN]] Autosomal recessive primary microcephaly. A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1. May give rise to a KMT2A/MLL1-CASC5 fusion protein. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Petrovic, A., Mosalaganti, S., Keller, J., Mattiuzzo, M., Overlack, K., Wohlgemuth, S., Pasqualato, S., Raunser, S., Musacchio, A.
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==Function==
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[[http://www.uniprot.org/uniprot/CASC5_HUMAN CASC5_HUMAN]] Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.<ref>PMID:15502821</ref> <ref>PMID:17981135</ref> <ref>PMID:18045986</ref> [[http://www.uniprot.org/uniprot/NSL1_HUMAN NSL1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:16585270</ref>
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Description: Structure of the Knl1/Nsl1 complex
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==About this Structure==
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[[4nf9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NF9 OCA].
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==Reference==
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<ref group="xtra">PMID:024530301</ref><references group="xtra"/><references/>
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[[Category: Keller, J.]]
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[[Category: Mattiuzzo, M.]]
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[[Category: Mosalaganti, S.]]
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[[Category: Musacchio, A.]]
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[[Category: Overlack, K.]]
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[[Category: Pasqualato, S.]]
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[[Category: Petrovic, A.]]
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[[Category: Raunser, S.]]
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[[Category: Wohlgemuth, S.]]
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[[Category: Cell cycle]]
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[[Category: Rwd domain]]

Revision as of 09:17, 19 March 2014

Template:STRUCTURE 4nf9

Contents

Structure of the Knl1/Nsl1 complex

Template:ABSTRACT PUBMED 24530301

Disease

[CASC5_HUMAN] Autosomal recessive primary microcephaly. A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1. May give rise to a KMT2A/MLL1-CASC5 fusion protein. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CASC5_HUMAN] Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.[1] [2] [3] [NSL1_HUMAN] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.[4]

About this Structure

4nf9 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S, Musacchio A. Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization. Mol Cell. 2014 Feb 20;53(4):591-605. doi: 10.1016/j.molcel.2014.01.019. Epub 2014, Feb 13. PMID:24530301 doi:http://dx.doi.org/10.1016/j.molcel.2014.01.019
  1. ↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol. 2004 Nov;6(11):1135-41. Epub 2004 Oct 24. PMID:15502821 doi:http://dx.doi.org/10.1038/ncb1187
  2. ↑ Kiyomitsu T, Obuse C, Yanagida M. Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell. 2007 Nov;13(5):663-76. PMID:17981135 doi:http://dx.doi.org/10.1016/j.devcel.2007.09.005
  3. ↑ Cheeseman IM, Hori T, Fukagawa T, Desai A. KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell. 2008 Feb;19(2):587-94. Epub 2007 Nov 28. PMID:18045986 doi:http://dx.doi.org/10.1091/mbc.E07-10-1051
  4. ↑ Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol. 2006 Apr 10;173(1):9-17. Epub 2006 Apr 3. PMID:16585270 doi:http://dx.doi.org/10.1083/jcb.200509158

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