This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3w2k
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-165== | |
| - | + | <StructureSection load='3w2k' size='340' side='right' caption='[[3w2k]], [[Resolution|resolution]] 1.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[3w2k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W2K FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KRO:5-[2-(4-FLUORO-3-METHYLPHENYL)ETHYL]-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>KRO</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w1a|3w1a]], [[3w1l|3w1l]], [[3w1m|3w1m]], [[3w1n|3w1n]], [[3w1p|3w1p]], [[3w1q|3w1q]], [[3w1r|3w1r]], [[3w1t|3w1t]], [[3w1u|3w1u]], [[3w1x|3w1x]], [[3w22|3w22]], [[3w23|3w23]], [[3w2j|3w2j]], [[3w2l|3w2l]], [[3w2m|3w2m]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w2k RCSB], [http://www.ebi.ac.uk/pdbsum/3w2k PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. | [[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]] |
| - | [[Category: Aoki, T | + | __TOC__ |
| - | [[Category: Balogun, E O | + | </StructureSection> |
| - | [[Category: Harada, S | + | [[Category: Trycc]] |
| - | [[Category: Honma, T | + | [[Category: Aoki, T]] |
| - | [[Category: Iida, M | + | [[Category: Balogun, E O]] |
| - | [[Category: Inaoka, D K | + | [[Category: Harada, S]] |
| - | [[Category: Inoue, M | + | [[Category: Honma, T]] |
| - | [[Category: Kita, K | + | [[Category: Iida, M]] |
| - | [[Category: Lee, N | + | [[Category: Inaoka, D K]] |
| - | [[Category: Matsuoka, S | + | [[Category: Inoue, M]] |
| - | [[Category: Nara, T | + | [[Category: Kita, K]] |
| - | [[Category: Sakamoto, K | + | [[Category: Lee, N]] |
| - | [[Category: Shiba, T | + | [[Category: Matsuoka, S]] |
| - | [[Category: Suzuki, S | + | [[Category: Nara, T]] |
| - | [[Category: Tabuchi, T | + | [[Category: Sakamoto, K]] |
| - | [[Category: Tanaka, A | + | [[Category: Shiba, T]] |
| + | [[Category: Suzuki, S]] | ||
| + | [[Category: Tabuchi, T]] | ||
| + | [[Category: Tanaka, A]] | ||
[[Category: Cytosol]] | [[Category: Cytosol]] | ||
[[Category: Dihydroorotate/orotate binding]] | [[Category: Dihydroorotate/orotate binding]] | ||
Revision as of 15:38, 24 December 2014
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-165
| |||||||||||
Categories: Trycc | Aoki, T | Balogun, E O | Harada, S | Honma, T | Iida, M | Inaoka, D K | Inoue, M | Kita, K | Lee, N | Matsuoka, S | Nara, T | Sakamoto, K | Shiba, T | Suzuki, S | Tabuchi, T | Tanaka, A | Cytosol | Dihydroorotate/orotate binding | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Rossmann fold
