Casein kinase
From Proteopedia
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[[2cmw]] – hCK1-γ1 + inhibitor | [[2cmw]] – hCK1-γ1 + inhibitor | ||
| - | [[2izr]], [[2izs]], [[2izs]], [[2izu]], [[2izt]] - hCK1-γ3 + inhibitor | + | [[2izr]], [[2izs]], [[2izs]], [[2izu]], [[2izt]], [[4g16]], [[4g17]], [[4hgl]], [[4hgs]] - hCK1-γ3 + inhibitor<br /> |
| - | + | [[3uys]] – hCK1-δ<br /> | |
| + | [[3uyt]], [[3uzp]], [[4hgt]], [[4hnf]], [[4kb8]], [[4kba]], [[4kbc]], [[4kbk]] – hCK1-δ + inhibitor<br /> | ||
[[1cki]] – rCK1-δ (mutant) – rat | [[1cki]] – rCK1-δ (mutant) – rat | ||
| - | [[1ckj]] - rCK1-δ (mutant) + WO4 | + | [[1ckj]] - rCK1-δ (mutant) + WO4<br /> |
| - | + | [[4jjr]] - CK1-δ - mouse<br /> | |
| + | [[4hok]] - hCK1-ε <br /> | ||
| + | [[4hni]] - hCK1-ε + inhibitor<br /> | ||
[[1csn]] – yCK1 + MgATP – fission yeast | [[1csn]] – yCK1 + MgATP – fission yeast | ||
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===CK2 catalytic subunit=== | ===CK2 catalytic subunit=== | ||
| - | [[1pjk]], [[3at2]] | + | [[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]] - hCK2 α subunit |
| - | + | ||
| - | [[ | + | |
| + | [[1na7]], [[3fwq]], [[3juh]] - hCK2 α subunit (mutant)<br /> | ||
| + | [[3axw]], [[3r0t]], [[3u4u]] – hCK2 α subunit + inhibitor<br /> | ||
| + | [[3u87]] – hCK2 α subunit + ATP analog<br /> | ||
| + | [[3q9w]], [[3q9x]] – hCK2 α subunit + emodin<br /> | ||
| + | [[3q9y]], [[3q9z]] – hCK2 α subunit + quinalizarin<br /> | ||
| + | [[3u9c]] – hCK2 α subunit + resorufin<br /> | ||
[[3ofm]] - hCK2 α’ subunit | [[3ofm]] - hCK2 α’ subunit | ||
[[2r7i]] - rCK2 α subunit | [[2r7i]] - rCK2 α subunit | ||
| - | [[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit | + | [[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit <br /> |
| + | [[1daw]], [[1day]] – mCK2 + Mg-AMPPNP <br /> | ||
| + | [[1f0q]], [[3pzh]] – mCK2 α subunit + emodin<br /> | ||
| + | [[1zoe]], [[1zog]], [[1zoh]] – mCK2 α subunit + TBB derivative<br /> | ||
===CK2 catalytic subunit binary complex=== | ===CK2 catalytic subunit binary complex=== | ||
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[[1lp4]] - mCK2 α subunit + Mg-AMPPNP | [[1lp4]] - mCK2 α subunit + Mg-AMPPNP | ||
| - | [[3nsz]] - hCK2 α subunit + AMPPN | + | [[3nsz]] - hCK2 α subunit + AMPPN<br /> |
| - | + | [[3w8l]] - hCK2 α subunit (mutant) + inositol hexakisphosphate<br /> | |
| + | [[4dgm]] - mCK2 α subunit + apigenin<br /> | ||
| + | [[4dgn]] - mCK2 α subunit + luteolin<br /> | ||
| + | [[4dgo]] - mCK2 α subunit + tyrphostin<br /> | ||
[[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 α subunit + inhibitor | [[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 α subunit + inhibitor | ||
| - | [[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]] - hCK2 α subunit + inhibitor | + | [[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]], [[4anm]], [[4grb]], [[4gub]] - hCK2 α subunit + inhibitor<br /> |
| - | + | [[4fbx]] - hCK2 α subunit + polypeptide inhibitor<br /> | |
| - | [[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor | + | [[4ib5]] - hCK2 α subunit + hCK2 β polypeptide <br /> |
| + | [[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor<br /> | ||
| + | [[4fi1]], [[4mwh]] - yCK2 α subunit + ATP<br /> | ||
===CK2 regulatory subunit=== | ===CK2 regulatory subunit=== | ||
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===CK2 catalytic + regulatory subunits=== | ===CK2 catalytic + regulatory subunits=== | ||
| - | [[1jwh]] - hCK2 α subunit + β subunit | + | [[1jwh]], [[4md7]] - hCK2 α subunit + β subunit<br /> |
| - | + | [[4dgl]], [[4md8]], [[4md9]] - hCK2 α subunit (mutant) + β subunit<br /> | |
[[1ds5]] - mCK2 α subunit + β subunit peptide | [[1ds5]] - mCK2 α subunit + β subunit peptide | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:05, 17 February 2014
Casein kinase (CK) is a protein kinase which functions as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one.
3D Structures of casein kinase
Updated on 17-February-2014
CK1
2c47 – hCK1-γ2 – human
2chl - hCK1-γ3
2cmw – hCK1-γ1 + inhibitor
2izr, 2izs, 2izs, 2izu, 2izt, 4g16, 4g17, 4hgl, 4hgs - hCK1-γ3 + inhibitor
3uys – hCK1-δ
3uyt, 3uzp, 4hgt, 4hnf, 4kb8, 4kba, 4kbc, 4kbk – hCK1-δ + inhibitor
1cki – rCK1-δ (mutant) – rat
1ckj - rCK1-δ (mutant) + WO4
4jjr - CK1-δ - mouse
4hok - hCK1-ε
4hni - hCK1-ε + inhibitor
1csn – yCK1 + MgATP – fission yeast
2csn, 1eh4 – yCK1 catalytic domain + inhibitor
CK2 catalytic subunit
1pjk, 3at2, 3q04, 3qa0, 3war - hCK2 α subunit
1na7, 3fwq, 3juh - hCK2 α subunit (mutant)
3axw, 3r0t, 3u4u – hCK2 α subunit + inhibitor
3u87 – hCK2 α subunit + ATP analog
3q9w, 3q9x – hCK2 α subunit + emodin
3q9y, 3q9z – hCK2 α subunit + quinalizarin
3u9c – hCK2 α subunit + resorufin
3ofm - hCK2 α’ subunit
2r7i - rCK2 α subunit
1lpu, 1lr4, 1jam - mCK2 α subunit
1daw, 1day – mCK2 + Mg-AMPPNP
1f0q, 3pzh – mCK2 α subunit + emodin
1zoe, 1zog, 1zoh – mCK2 α subunit + TBB derivative
CK2 catalytic subunit binary complex
2pvr - hCK2 α subunit + sulfate
3rp0 – hCK2 α subunit + α’ subunit + ATP analog
3bqc, 3c13 - hCK2 α subunit + emodin
1j91 - mCK2 α subunit + ATP competitive inhibitor - maize
1lp4 - mCK2 α subunit + Mg-AMPPNP
3nsz - hCK2 α subunit + AMPPN
3w8l - hCK2 α subunit (mutant) + inositol hexakisphosphate
4dgm - mCK2 α subunit + apigenin
4dgn - mCK2 α subunit + luteolin
4dgo - mCK2 α subunit + tyrphostin
1m2p, 1m2q, 1m2r, 1om1, 2oxd, 2oxx, 2oxy, 2qc6, 2pvh, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg, 3pwd - mCK2 α subunit + inhibitor
3e3b, 2zjw, 3h30, 3mb6, 3mb7, 3nga, 3rps, 3pe1, 3pe2, 3amy, 3at3, 3at4, 4anm, 4grb, 4gub - hCK2 α subunit + inhibitor
4fbx - hCK2 α subunit + polypeptide inhibitor
4ib5 - hCK2 α subunit + hCK2 β polypeptide
2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 3be9 - mCK2 α subunit (mutant) + inhibitor
4fi1, 4mwh - yCK2 α subunit + ATP
CK2 regulatory subunit
2r6m - rCK2 β subunit
1rqf - CK2 β subunit + cyclin-dependent kinase peptide – Xenopus laevis
CK2 catalytic + regulatory subunits
1jwh, 4md7 - hCK2 α subunit + β subunit
4dgl, 4md8, 4md9 - hCK2 α subunit (mutant) + β subunit
1ds5 - mCK2 α subunit + β subunit peptide
