NAD(P) transhydrogenase

From Proteopedia

(Difference between revisions)

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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+===PTH domain I===
+[[1l7d]] – RrPTH domain I – ''Rhodospirillum rubrum'' <br />
+[[1l7e]] – RrPTH domain I + NAD <br />
+[[1x13]] – EcPTH domain I – ''Escherichia coli'' <br />
+[[1x14]], [[1x15]] – EcPTH domain I + NAD <br />
+[[4dio]] – PTH domain I – ''Sinorhizobium meliloti''<br />
 ===PTH domain III===
-[[1e3t]] – RrPTH domain III + NADP – Rhodospirillum rubrum - NMR<br />
+[[1e3t]] – RrPTH domain III + NADP - NMR<br />
 [[1pno]] – RrPTH domain III + NADP <br />
 [[1pnq]] – RrPTH domain III + NADPH <br />
+[[1d4o]] – bPTH domain III + NADP - bovine<br />
+[[1djl]], [[1u31]] – hPTH domain III + NADP - human<br />
+[[1pt9]] – hPTH domain III + NADP analog<br />
 ===PTH domain I+III===
 [[1hzz]], [[1u28]], [[1u2d]], [[1xlt]] – RrPTH domain I+III + NADP + NAD<br />
+[[1f8g]] – RrPTH domain I+III + NAD<br />
 [[1nm5]], [[2fr8]], [[2fsv]] – RrPTH domain I+III (mutant) + NADP + NAD<br />
 [[1ptj]], [[1u2g]], [[2frd]], [[2oo5]] – RrPTH domain I+III + NADP + NAD derivative<br />
 [[2oor]] – RrPTH domain I+III + NADP derivative + NAD<br />
-[[2bru]] – PTH domain I+III + NADP + NAD – Escherichia coli - NMR<br />
+[[2bru]] – EcPTH domain I+III + NADP + NAD - NMR<br />
+[[4j16]], [[4j1t]] – PTH domain I+III + NADP + NAD – ''Thermus thermophilus''<br />
 [[Category:Topic Page]]

Revision as of 10:25, 30 March 2014

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Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry 1u28)

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NAD(P) transhydrogenase (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change. PTH uses FAD as cofactor. PTH is composed of 3 domains.:

Domain I binds NAD(+)/NADH.
Domain II is a membrane-spanning domain.
Domain III binds NADP(+)/NADPH.

PTH is composed of 2 subunits. Subunit beta contains domain III and part of II.

1 3D structures of NAD(P) transhydrogenase

3D structures of NAD(P) transhydrogenase

Updated on 30-March-2014

PTH domain I

1l7d – RrPTH domain I – Rhodospirillum rubrum
1l7e – RrPTH domain I + NAD
1x13 – EcPTH domain I – Escherichia coli
1x14, 1x15 – EcPTH domain I + NAD
4dio – PTH domain I – Sinorhizobium meliloti

PTH domain III

1e3t – RrPTH domain III + NADP - NMR
1pno – RrPTH domain III + NADP
1pnq – RrPTH domain III + NADPH
1d4o – bPTH domain III + NADP - bovine
1djl, 1u31 – hPTH domain III + NADP - human
1pt9 – hPTH domain III + NADP analog

PTH domain I+III

1hzz, 1u28, 1u2d, 1xlt – RrPTH domain I+III + NADP + NAD
1f8g – RrPTH domain I+III + NAD
1nm5, 2fr8, 2fsv – RrPTH domain I+III (mutant) + NADP + NAD
1ptj, 1u2g, 2frd, 2oo5 – RrPTH domain I+III + NADP + NAD derivative
2oor – RrPTH domain I+III + NADP derivative + NAD
2bru – EcPTH domain I+III + NADP + NAD - NMR
4j16, 4j1t – PTH domain I+III + NADP + NAD – Thermus thermophilus