User:Chengfeng Ren/IFN beta 1a
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(→IFN Categories and IFNβ-1a sources) |
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==IFN Categories and IFNβ-1a sources== | ==IFN Categories and IFNβ-1a sources== | ||
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| + | Interferons (IFNs) are a family of helical cytokines that mediate | ||
| + | antiviral, antiproliferative, and immune modulatory activities in | ||
| + | response to biological and chemical stimuli~Stewart, 1979; Sen & | ||
| + | Lengyel, 1992; Tyring, 1995!. Two types of IFN are recognized on | ||
| + | the basis of their physical and biological properties; type I, which | ||
| + | contains the monomeric IFNs-a,-b,-t, and -v, and type II, the | ||
| + | only member of which is the dimeric IFN-g. Representatives of all | ||
| + | type I and type II IFNs are found in humans, except for IFN-t, | ||
| + | which is found only in ruminant ungulates~Li & Roberts, 1994; | ||
| + | Bazer et al., 1997!. There are 12 different human IFNs-a~each one | ||
| + | comprising a different subtype! although 14 different genes have | ||
| + | been identified, whereas human IFN-b, IFN-v, and IFN-gare | ||
| + | encoded by single genes~Weissmann & Weber, 1986; Diaz et al., | ||
| + | 1994; Pestka, 1997a, 1997b!. | ||
| + | |||
==Structure info. of IFNβ-1a== | ==Structure info. of IFNβ-1a== | ||
==IFNβ-1a biological activity and therapeutic effects== | ==IFNβ-1a biological activity and therapeutic effects== | ||
Revision as of 16:11, 6 December 2013
Contents |
IFN Categories and IFNβ-1a sources
Interferons (IFNs) are a family of helical cytokines that mediate antiviral, antiproliferative, and immune modulatory activities in response to biological and chemical stimuli~Stewart, 1979; Sen & Lengyel, 1992; Tyring, 1995!. Two types of IFN are recognized on the basis of their physical and biological properties; type I, which contains the monomeric IFNs-a,-b,-t, and -v, and type II, the only member of which is the dimeric IFN-g. Representatives of all type I and type II IFNs are found in humans, except for IFN-t, which is found only in ruminant ungulates~Li & Roberts, 1994; Bazer et al., 1997!. There are 12 different human IFNs-a~each one comprising a different subtype! although 14 different genes have been identified, whereas human IFN-b, IFN-v, and IFN-gare encoded by single genes~Weissmann & Weber, 1986; Diaz et al., 1994; Pestka, 1997a, 1997b!.
Structure info. of IFNβ-1a
IFNβ-1a biological activity and therapeutic effects
Mechanism of action for IFNβ-1a
Reference
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