User:Chengfeng Ren/IFN beta 1a
From Proteopedia
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(→IFN Categories and IFNβ-1a sources) |
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Interferons (IFNs) are a family of helical cytokines that mediate | Interferons (IFNs) are a family of helical cytokines that mediate | ||
antiviral, antiproliferative, and immune modulatory activities in | antiviral, antiproliferative, and immune modulatory activities in | ||
| - | response to biological and chemical stimuli | + | response to biological and chemical stimuli. Two types of IFN are recognized on |
| - | + | ||
the basis of their physical and biological properties; type I, which | the basis of their physical and biological properties; type I, which | ||
contains the monomeric IFNs-a,-b,-t, and -v, and type II, the | contains the monomeric IFNs-a,-b,-t, and -v, and type II, the | ||
only member of which is the dimeric IFN-g. Representatives of all | only member of which is the dimeric IFN-g. Representatives of all | ||
type I and type II IFNs are found in humans, except for IFN-t, | type I and type II IFNs are found in humans, except for IFN-t, | ||
| - | which is found only in ruminant ungulates | + | which is found only in ruminant ungulates. There are 12 different human IFNs-a;each one |
| - | + | comprising a different subtype,although 14 different genes have | |
| - | comprising a different subtype | + | been identified, whereas human IFN-b, IFN-v, and IFN-γare |
| - | been identified, whereas human IFN-b, IFN-v, and IFN- | + | encoded by single genes. |
| - | encoded by single genes | + | |
| - | + | ||
==Structure info. of IFNβ-1a== | ==Structure info. of IFNβ-1a== | ||
Revision as of 16:14, 6 December 2013
Contents |
IFN Categories and IFNβ-1a sources
Interferons (IFNs) are a family of helical cytokines that mediate antiviral, antiproliferative, and immune modulatory activities in response to biological and chemical stimuli. Two types of IFN are recognized on the basis of their physical and biological properties; type I, which contains the monomeric IFNs-a,-b,-t, and -v, and type II, the only member of which is the dimeric IFN-g. Representatives of all type I and type II IFNs are found in humans, except for IFN-t, which is found only in ruminant ungulates. There are 12 different human IFNs-a;each one comprising a different subtype,although 14 different genes have been identified, whereas human IFN-b, IFN-v, and IFN-γare encoded by single genes.
Structure info. of IFNβ-1a
IFNβ-1a biological activity and therapeutic effects
Mechanism of action for IFNβ-1a
Reference
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