User:Chengfeng Ren/IFN beta 1a

From Proteopedia

Revision as of 16:31, 6 December 2013

IFN Categories and IFNβ-1a sources

Interferons (IFNs) are a family of helical cytokines that mediate antiviral, antiproliferative, and immune modulatory activities in response to biological and chemical stimuli. Two types of IFN are recognized on the basis of their physical and biological properties; type I, which Image:IFN Categories.jpg contains the monomeric IFNs-α,-β,-τ, and -ω, and type II, the only member of which is the dimeric IFN-γ. Representatives of all type I and type II IFNs are found in humans, except for IFN-τ, which is found only in ruminant ungulates. There are 12 different human IFNs-α;each one comprising a different subtype,although 14 different genes have been identified, whereas human IFN-β, IFN-ω, and IFN-γare encoded by single genes[1].

Interferon-βhas two subtyes, interferon-β-1a and interferon-β-1b. Interferon-β-1a is naturally expressed in numerous cell types in human, including fibroblasts, endothelial cells, epithelial cells and various leukocytes, however,Interferon-β-1b is produced in modified E. coli.

Structure info. of IFNβ-1a

IFNβ-1a biological activity and therapeutic effects

Mechanism of action for IFNβ-1a

Reference

[1]Protein Science (1999),8:1867–1877