Sandbox Reserved 769

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'''Gene Name''': trpA, trpB<ref name="cite2">http://www.uniprot.org/uniprot/P00929</ref>
'''Gene Name''': trpA, trpB<ref name="cite2">http://www.uniprot.org/uniprot/P00929</ref>
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'''Organism''': ''Salmonella typhimurium'' (strain LT2) <ref name="info">http://www.uniprot.org/uniprot/P00929</ref>
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'''Organism''': ''Salmonella typhimurium'' (strain LT2) <ref name="cite2">http://www.uniprot.org/uniprot/P00929</ref>
'''Classification''': Lyase <ref name="cite3">http://oca.weizmann.ac.il/oca-bin/ocashort</ref>
'''Classification''': Lyase <ref name="cite3">http://oca.weizmann.ac.il/oca-bin/ocashort</ref>
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'''Length''': trpA: 268 AA <ref name="info">http://www.uniprot.org/uniprot/P00929</ref> trpB: 397 AA <ref name="info">http://www.uniprot.org/uniprot/P0A2K1</ref>
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'''Length''': trpA: 268 AA <ref name="cite2">http://www.uniprot.org/uniprot/P00929</ref> trpB: 397 AA <ref name="info">http://www.uniprot.org/uniprot/P0A2K1</ref>
'''Molecular Weight''': 72012.45 Da <ref name="cite4">http://www.rcsb.org/pdb/explore.do?structureId=1QOP</ref>
'''Molecular Weight''': 72012.45 Da <ref name="cite4">http://www.rcsb.org/pdb/explore.do?structureId=1QOP</ref>
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'''Chains''': A, B <ref name="cite2">http://oca.weizmann.ac.il/oca-bin/ocashort</ref>
'''Chains''': A, B <ref name="cite2">http://oca.weizmann.ac.il/oca-bin/ocashort</ref>
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'''Ligands''': Sodium Ion ([http://oca.weizmann.ac.il/oca-bin/send-het?NA]), pyridoxal-5'-phosphate ([http://oca.weizmann.ac.il/oca-bin/send-het?PLP])<ref name="cite2">http://oca.weizmann.ac.il/oca-bin/ocashort</ref>
+
'''Ligands''': Sodium Ion ([http://oca.weizmann.ac.il/oca-bin/send-het?NA]), pyridoxal-5'-phosphate ([http://oca.weizmann.ac.il/oca-bin/send-het?PLP])<ref name="cite3">http://oca.weizmann.ac.il/oca-bin/ocashort</ref>

Revision as of 19:30, 6 December 2013

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This Sandbox is Reserved from Sep 25, 2013, through Mar 31, 2014 for use in the course "BCH455/555 Proteins and Molecular Mechanisms" taught by Michael B. Goshe at the North Carolina State University. This reservation includes Sandbox Reserved 299, Sandbox Reserved 300 and Sandbox Reserved 760 through Sandbox Reserved 779.
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Structure of a tryptophan synthase quinonoid intermediate.

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Tryptophan Synthase

Tryptophan synthase is an enzyme that catalyzes the final two steps in the biosynthesis of tryptophan. It is commonly found in Eubacteria, Archaebacteria, Protista, Fungi, and Plantae. However, it is absent from Animalia. [1]

Tryptophan synthase is a classic enzyme that channels a metabolic intermediate, indole

Contents


General Information

Gene Name: trpA, trpB[2]

Organism: Salmonella typhimurium (strain LT2) [2]

Classification: Lyase [3]

Length: trpA: 268 AA [2] trpB: 397 AA [1]

Molecular Weight: 72012.45 Da [4]

Isoelectric Point: 5.62 [5]

Chains: A, B [2]

Ligands: Sodium Ion ([1]), pyridoxal-5'-phosphate ([2])[3]


Structure

Alpha Subunit

Beta Subunit

Enzymatic Mechanism

References

  1. 1.0 1.1 http://en.wikipedia.org/wiki/Tryptophan_synthase
  2. 2.0 2.1 2.2 2.3 http://www.uniprot.org/uniprot/P00929
  3. 3.0 3.1 http://oca.weizmann.ac.il/oca-bin/ocashort
  4. http://www.rcsb.org/pdb/explore.do?structureId=1QOP
  5. http://mips.helmholtz-muenchen.de/genre/proj/FGDB/singleGeneReport.html?entry=FGSG_10743
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