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Fibrinogen

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{{STRUCTURE_1n73| PDB=1n73 | SIZE=350| SCENE= |right|CAPTION='Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue) and Ca+2 ion,[[1n73]].'}}
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{{STRUCTURE_1n73| PDB=1n73 | SIZE=350| SCENE= |right|CAPTION=Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion,[[1n73]].}}

Revision as of 11:12, 11 December 2013

Image:3hus2.jpg
Crystal Structure of Fibrinogen with peptide ligand, 3hus


Template:STRUCTURE 1n73














Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]

Contents


3D Structure of Fibrinogen

Updated on 11-December-2013

Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).

Fibrinogen α+β+γ chains

3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2xnx, 2xny - hFba+hFbb+hFbg + M1 protein
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg – cow
1jy2 - cFba+cFbb+cFbg proteolytic fragment
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg

Fibrinogen α chain

1fzd – hFba EC domain
1bbr – hFba+cε-thrombin
2jor – cFba – NMR
2baf – cFba

Fibrinogen β chain

1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D

Fibrinogen γ chain

2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid – hFbg
3fib – hFbg C terminal
1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum
2hwl – hFbg peptide+prothrombin


References

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

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