4c5x
From Proteopedia
(Difference between revisions)
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| - | + | ==Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification== | |
| - | + | <StructureSection load='4c5x' size='340' side='right' caption='[[4c5x]], [[Resolution|resolution]] 1.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4c5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C5X FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c63|4c63]], [[4c64|4c64]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c5x RCSB], [http://www.ebi.ac.uk/pdbsum/4c5x PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Transcription factor binding and high resolution crystallographic studies (1.3 A) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions. | ||
| - | + | Structural insights into how 5-hydroxymethylation influences transcription factor binding.,Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ Chem Commun (Camb). 2013 Nov 29. PMID:24287551<ref>PMID:24287551</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Brown, T | + | == References == |
| - | [[Category: El-Sagheer, A H | + | <references/> |
| - | [[Category: McDonough, M | + | __TOC__ |
| - | [[Category: Schofield, C J | + | </StructureSection> |
| + | [[Category: Brown, T]] | ||
| + | [[Category: El-Sagheer, A H]] | ||
| + | [[Category: McDonough, M]] | ||
| + | [[Category: Schofield, C J]] | ||
[[Category: Cytosine modification]] | [[Category: Cytosine modification]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
Revision as of 13:05, 4 January 2015
Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification
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