4blb

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{{STRUCTURE_4blb| PDB=4blb | SCENE= }}
{{STRUCTURE_4blb| PDB=4blb | SCENE= }}
===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===
===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===
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{{ABSTRACT_PUBMED_16459298}}
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{{ABSTRACT_PUBMED_24311597}}
==Function==
==Function==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016459298</ref><references group="xtra"/><references/>
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<ref group="xtra">PMID:024311597</ref><references group="xtra"/><references/>
[[Category: Human]]
[[Category: Human]]
[[Category: Cherry, A L.]]
[[Category: Cherry, A L.]]

Revision as of 07:58, 18 December 2013

Template:STRUCTURE 4blb

Contents

Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex

Template:ABSTRACT PUBMED 24311597

Function

[MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [GLI1_HUMAN] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.[1] [2]

About this Structure

4blb is a 8 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Cherry AL, Finta C, Karlstrom M, Jin Q, Schwend T, Astorga-Wells J, Zubarev RA, Del Campo M, Criswell AR, de Sanctis D, Jovine L, Toftgard R. Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2563-79. doi:, 10.1107/S0907444913028473. Epub 2013 Nov 19. PMID:24311597 doi:http://dx.doi.org/10.1107/S0907444913028473
  1. ↑ Murone M, Luoh SM, Stone D, Li W, Gurney A, Armanini M, Grey C, Rosenthal A, de Sauvage FJ. Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol. 2000 May;2(5):310-2. PMID:10806483 doi:10.1038/35010610
  2. ↑ Koyabu Y, Nakata K, Mizugishi K, Aruga J, Mikoshiba K. Physical and functional interactions between Zic and Gli proteins. J Biol Chem. 2001 Mar 9;276(10):6889-92. Epub 2001 Jan 12. PMID:11238441 doi:http://dx.doi.org/10.1074/jbc.C000773200

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OCA

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