3wn7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3wn7" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_3wn7| PDB=3wn7 | SCENE= }}
 +
===Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor===
-
The entry 3wn7 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> [[http://www.uniprot.org/uniprot/NF2L2_MOUSE NF2L2_MOUSE]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:9887101</ref>
-
Authors: Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., Yamamoto, M.
+
==About this Structure==
 +
[[3wn7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WN7 OCA].
-
Description: Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Fukutomi, T.]]
 +
[[Category: Mizushima, T.]]
 +
[[Category: Ohuchi, N.]]
 +
[[Category: Takagi, K.]]
 +
[[Category: Yamamoto, M.]]
 +
[[Category: Beta-propeller]]
 +
[[Category: Degron]]
 +
[[Category: Kelch motif]]
 +
[[Category: Transcription]]

Revision as of 10:22, 25 December 2013

Template:STRUCTURE 3wn7

Contents

Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor

Function

[KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).[1] [2] [NF2L2_MOUSE] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.[3]

About this Structure

3wn7 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999 Jan 1;13(1):76-86. PMID:9887101
  2. ↑ McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem. 2003 Jun 13;278(24):21592-600. Epub 2003 Apr 7. PMID:12682069 doi:10.1074/jbc.M300931200
  3. ↑ Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999 Jan 1;13(1):76-86. PMID:9887101

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3wn7"
Personal tools