2rf2

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[[Image:2rf2.jpg|left|200px]]<br /><applet load="2rf2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2rf2.jpg|left|200px]]
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caption="2rf2, resolution 2.4&Aring;" />
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'''HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)'''<br />
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{{Structure
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|PDB= 2rf2 |SIZE=350|CAPTION= <scene name='initialview01'>2rf2</scene>, resolution 2.4&Aring;
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|SITE= <scene name='pdbsite=AC1:Mrx+Binding+Site+For+Residue+A+561'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MRX:'>MRX</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
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|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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}}
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'''HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2RF2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MRX:'>MRX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Known structural/functional Site: <scene name='pdbsite=AC1:Mrx+Binding+Site+For+Residue+A+561'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF2 OCA].
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2RF2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF2 OCA].
==Reference==
==Reference==
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Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. Epub 2007 Nov 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18083561 18083561]
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Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. Epub 2007 Nov 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18083561 18083561]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
[[Category: MRX]]
[[Category: MRX]]
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[[Category: aids]]
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[[Category: aid]]
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[[Category: ais]]
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[[Category: ai]]
[[Category: aspartyl protease]]
[[Category: aspartyl protease]]
[[Category: capsid maturation]]
[[Category: capsid maturation]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:35:27 2008''

Revision as of 16:35, 20 March 2008

Image:2rf2.jpg


PDB ID 2rf2

Drag the structure with the mouse to rotate
, resolution 2.4Å
Sites:
Ligands:
Gene: gag-pol (Human immunodeficiency virus 1)
Activity: RNA-directed DNA polymerase, with EC number 2.7.7.49
Coordinates: save as pdb, mmCIF, xml



HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)


Overview

This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.

About this Structure

2RF2 is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. Epub 2007 Nov 28. PMID:18083561

Page seeded by OCA on Thu Mar 20 18:35:27 2008

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