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4np9

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4np9| PDB=4np9 | SCENE= }}
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===Structure of Rabphilin C2A domain bound to IP3===
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{{ABSTRACT_PUBMED_24302762}}
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The entry 4np9 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RP3A_RAT RP3A_RAT]] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
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Authors: Guillen, J., Ferrer-Orta, C., Buxaderas, M., Perez-sanchez, D., Guerrero-Valero, M., Luengo-Gil, G., Pous, J., Guerra, P., Gomez-Fernandez, J., Verdaguer, N, Corbalan-Garcia, S.
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==About this Structure==
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[[4np9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NP9 OCA].
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Description: Structure of Rabphilin C2A domain bound to PI(3,4,5)P3
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==Reference==
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<ref group="xtra">PMID:024302762</ref><references group="xtra"/><references/>
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[[Category: Buxaderas, M.]]
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[[Category: Corbalan-Garcia, S.]]
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[[Category: Ferrer-Orta, C.]]
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[[Category: Gomez-Fernandez, J C.]]
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[[Category: Guerra, P.]]
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[[Category: Guerrero-Valero, M.]]
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[[Category: Guillen, J.]]
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[[Category: Luengo-Gil, G.]]
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[[Category: Perez-Sanchez, D.]]
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[[Category: Pous, J.]]
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[[Category: Verdaguer, N.]]
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[[Category: C-2 domain fold]]
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[[Category: C2 domain]]
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[[Category: C2a]]
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[[Category: Calcium binding]]
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[[Category: Exophilin-1]]
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[[Category: Protein transport]]
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[[Category: Rabphilin-3a]]
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[[Category: Synaptic exocytosis metal-binding]]

Revision as of 10:19, 25 December 2013

Template:STRUCTURE 4np9

Contents

Structure of Rabphilin C2A domain bound to IP3

Template:ABSTRACT PUBMED 24302762

Function

[RP3A_RAT] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

About this Structure

4np9 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Guillen J, Ferrer-Orta C, Buxaderas M, Perez-Sanchez D, Guerrero-Valero M, Luengo-Gil G, Pous J, Guerra P, Gomez-Fernandez JC, Verdaguer N, Corbalan-Garcia S. Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20503-8. doi:, 10.1073/pnas.1316179110. Epub 2013 Dec 3. PMID:24302762 doi:http://dx.doi.org/10.1073/pnas.1316179110

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