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4nqw
From Proteopedia
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| - | + | {{STRUCTURE_4nqw| PDB=4nqw | SCENE= }} | |
| + | ===Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [[http://www.uniprot.org/uniprot/RSKA_MYCTU RSKA_MYCTU]] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83. | ||
| - | + | ==About this Structure== | |
| - | + | [[4nqw]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. | |
| - | + | [[Category: Gopal, B.]] | |
| + | [[Category: Shukla, J K.]] | ||
| + | [[Category: Anti-sigma factor]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Dna binding protein-protein binding complex]] | ||
| + | [[Category: Promoter dna binding and transcription initiation]] | ||
| + | [[Category: Sigma factor]] | ||
| + | [[Category: Transcription initiation]] | ||
Revision as of 06:53, 22 January 2014
Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA
Function
[SIGK_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [RSKA_MYCTU] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.
About this Structure
4nqw is a 2 chain structure. This structure supersedes the now removed PDB entry 3vdo. Full crystallographic information is available from OCA.
