4m2z

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{{STRUCTURE_4m2z| PDB=4m2z | SCENE= }}
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==Crystal structure of RNASE III complexed with double-stranded RNA and CMP (TYPE II CLEAVAGE)==
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===Crystal structure of RNASE III complexed with double-stranded RNA and CMP (TYPE II CLEAVAGE)===
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<StructureSection load='4m2z' size='340' side='right' caption='[[4m2z]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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{{ABSTRACT_PUBMED_24274754}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4m2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M2Z FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nug|2nug]], [[4m30|4m30]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aq_946, rnc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m2z RCSB], [http://www.ebi.ac.uk/pdbsum/4m2z PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/RNC_AQUAE RNC_AQUAE]] Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.<ref>PMID:21138964</ref> <ref>PMID:16439209</ref>
[[http://www.uniprot.org/uniprot/RNC_AQUAE RNC_AQUAE]] Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.<ref>PMID:21138964</ref> <ref>PMID:16439209</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RNase III is a global regulator of gene expression in Escherichia coli that is instrumental in the maturation of ribosomal and other structural RNAs. We examine here how RNase III itself is regulated in response to growth and other environmental changes encountered by the cell and how, by binding or processing double-stranded RNA (dsRNA) intermediates, RNase III controls the expression of genes. Recent insight into the mechanism of dsRNA binding and processing, gained from structural studies of RNase III, is reviewed. Structural studies also reveal new cleavage sites in the enzyme that can generate longer 3' overhangs.
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RNase III: Genetics and Function; Structure and Mechanism.,Court DL, Gan J, Liang YH, Shaw GX, Tropea JE, Costantino N, Waugh DS, Ji X Annu Rev Genet. 2013 Nov 23;47:405-31. doi: 10.1146/annurev-genet-110711-155618. PMID:24274754<ref>PMID:24274754</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4m2z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2Z OCA].
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</div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:024274754</ref><references group="xtra"/><references/>
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*[[Ribonuclease|Ribonuclease]]
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*[[Temp|Temp]]
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*[[User:Jaime.Prilusky/Test/tree|User:Jaime.Prilusky/Test/tree]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aquae]]
[[Category: Ribonuclease III]]
[[Category: Ribonuclease III]]
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[[Category: Gan, J.]]
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[[Category: Gan, J]]
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[[Category: Ji, X.]]
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[[Category: Ji, X]]
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[[Category: Liang, Y H.]]
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[[Category: Liang, Y H]]
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[[Category: Shaw, G X.]]
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[[Category: Shaw, G X]]
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[[Category: Tropea, J E.]]
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[[Category: Tropea, J E]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh, D S]]
[[Category: Dsrna]]
[[Category: Dsrna]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 02:00, 25 December 2014

Crystal structure of RNASE III complexed with double-stranded RNA and CMP (TYPE II CLEAVAGE)

4m2z, resolution 2.85Å

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