2rje

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[[Image:2rje.gif|left|200px]]<br /><applet load="2rje" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2rje.gif|left|200px]]
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caption="2rje, resolution 1.86&Aring;" />
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'''Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), orthorhombic form II'''<br />
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{{Structure
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|PDB= 2rje |SIZE=350|CAPTION= <scene name='initialview01'>2rje</scene>, resolution 1.86&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY=
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|GENE= L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), orthorhombic form II'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2RJE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJE OCA].
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2RJE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJE OCA].
==Reference==
==Reference==
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L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18026117 18026117]
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L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18026117 18026117]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: repressor]]
[[Category: repressor]]
[[Category: sgc]]
[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: structural genomics consortium]]
[[Category: transcription]]
[[Category: transcription]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:47:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:36:47 2008''

Revision as of 16:36, 20 March 2008

Image:2rje.gif


PDB ID 2rje

Drag the structure with the mouse to rotate
, resolution 1.86Å
Ligands:
Gene: L3MBTL, KIAA0681, L3MBT (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), orthorhombic form II


Overview

Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.

About this Structure

2RJE is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117

Page seeded by OCA on Thu Mar 20 18:36:47 2008

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