Galactose oxidase

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{{STRUCTURE_1gog| PDB=1gog | SIZE=400| SCENE= |right|CAPTION=Galactose oxidase with Cu+2 (orange) and Na+ ions (purple), [[1gog]] }}
{{STRUCTURE_1gog| PDB=1gog | SIZE=400| SCENE= |right|CAPTION=Galactose oxidase with Cu+2 (orange) and Na+ ions (purple), [[1gog]] }}
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== Function ==
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'''Galactose oxidase''' (GAO) catalyzes the oxidation of D-galactose using O2 to D-galacto-hexodialdose and hydrogen peroxide. GAO catalytic motif is a free radical-coupled copper<ref>PMID:7929198</ref>.
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== Structural highlights ==
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'''Galactose oxidase''' (GAO) catalyzes the oxidation of D-galactose using O2 to D-galacto-hexodialdose and hydrogen peroxide. GAO uses copper and active site post-translational cross-linking of Cys228 and Tyr272 via a thioether bond for activity. GAO catalytic motif is a free radical-coupled copper.
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GAO uses copper and active site post-translational cross-linking of Cys228 and Tyr272 via a thioether bond for activity.
==3D structures of galactose oxidase==
==3D structures of galactose oxidase==
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[[2vz1]] – GzGAO premature<br />
[[2vz1]] – GzGAO premature<br />
[[2vz3]] - GzGAO
[[2vz3]] - GzGAO
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:17, 3 March 2016

Template:STRUCTURE 1gog

Contents

Function

Galactose oxidase (GAO) catalyzes the oxidation of D-galactose using O2 to D-galacto-hexodialdose and hydrogen peroxide. GAO catalytic motif is a free radical-coupled copper[1].

Structural highlights

GAO uses copper and active site post-translational cross-linking of Cys228 and Tyr272 via a thioether bond for activity.

3D structures of galactose oxidase

Updated on 03-March-2016

1gof, 1gog, 1goh – GAO – Hypomyces rosellus
1k3i – FuGAO precursor – Fusarium
1t2x – FuGAO (mutant)
2eib, 2eic, 2eid, 2wq8 - GzGAO (mutant) – Gibberella zeae
2eie – GzGAO + N3
2jkx – GzGAO no Cu
2vz1 – GzGAO premature
2vz3 - GzGAO

References

  1. ↑ Baron AJ, Stevens C, Wilmot C, Seneviratne KD, Blakeley V, Dooley DM, Phillips SE, Knowles PF, McPherson MJ. Structure and mechanism of galactose oxidase. The free radical site. J Biol Chem. 1994 Oct 7;269(40):25095-105. PMID:7929198

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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