Glucocorticoid receptor
From Proteopedia
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[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | [[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | ||
| - | [[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA | + | [[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> |
| + | [[4hn5]], [[4hn6]] - hGCR DBD + DNA – human<br /> | ||
'''Glucocorticoid receptor LBD domain''' | '''Glucocorticoid receptor LBD domain''' | ||
| - | [[1m2z]], [[3cld]] - hGCR LBD (mutant) + NCOA2 peptide + steroid | + | [[1m2z]], [[3cld]], [[3bqd]], [[4lsj]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> |
[[3e7c]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroid<br />al agonist | [[3e7c]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroid<br />al agonist | ||
[[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> | [[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> | ||
Revision as of 11:43, 11 March 2014
Template:STRUCTURE 3g6r Glucocorticoid receptor (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD); hinge region; ligand-binding domain (LBD) and C terminal domain. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones.
3D structures of glucocorticoid receptor
Updated on 11-March-2014
Glucocorticoid receptor DBD domain
1gdc, 2gda, 1rgd – rGCR DBD – NMR – rat
3g9p, 3fyl, 3g6p, 3g6q, 3g6r, 3g6t, 3g6u, 3g8u, 3g8x, 3g97, 3g99, 3g9i, 3g9m, 3g9j, 3g9o, 1glu, 1lat, 1r4o, 1r4r - rGCR DBD + DNA
4hn5, 4hn6 - hGCR DBD + DNA – human
Glucocorticoid receptor LBD domain
1m2z, 3cld, 3bqd, 4lsj - hGCR LBD (mutant) + NCOA2 peptide + steroid
3e7c - hGCR LBD (mutant) + NCOA2 peptide + non-steroid
al agonist
3k23 - hGCR LBD (mutant) + NCOA2 peptide + prolinamide
3k22 - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide
3h52 - hGCR LBD (mutant) + NCOA1 peptide + steroid
3gn8 - hGCR LBD + NCOA2 peptide + steroid
3ry9 - GCR LBD ancestral + steroid
4e2j - GCR LBD ancestral + NCOA2 peptide + steroid
3mne, 3mno, 3mnp - GCR LBD (mutant) + NCOA2 peptide + steroid
– mouse
Glucocorticoid receptor LBD+hinge domains
1nhz – hGCR LBD+hinge (mutant) + steroid
1p93 - hGCR LBD+hinge (mutant) + NCOA2 peptide + steroid
