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2m2v

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'''Unreleased structure'''
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{{STRUCTURE_2m2v| PDB=2m2v | SCENE= }}
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===African Swine Fever Virus Pol X in the ternary complex with MgdGTP and DNA===
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{{ABSTRACT_PUBMED_24617852}}
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The entry 2m2v is ON HOLD until Apr 03 2015
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==Function==
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[[http://www.uniprot.org/uniprot/DPOLX_ASFB7 DPOLX_ASFB7]] Error-prone polymerase lacking a proofreading 3'-5' exonuclease which plays a role in viral DNA repair. Specifically binds intermediates in the single-nucleotide base-excision repair process. Also catalyzes DNA polymerization with low nucleotide-insertion fidelity. Together with the viral DNA ligase, fills the single nucleotide gaps generated by the AP endonuclease.<ref>PMID:12595253</ref> <ref>PMID:11685239</ref>
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Authors: Wu, W., Su, M., Tsai, M.
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==About this Structure==
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[[2m2v]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2V OCA].
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Description: African Swine Fever Virus Pol X in the ternary complex with MgdGTP and DNA
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==Reference==
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<ref group="xtra">PMID:024617852</ref><references group="xtra"/><references/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Su, M.]]
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[[Category: Tsai, M.]]
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[[Category: Wu, W.]]
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[[Category: Dna polymerase]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Transferase]]

Revision as of 09:20, 2 April 2014

Template:STRUCTURE 2m2v

Contents

African Swine Fever Virus Pol X in the ternary complex with MgdGTP and DNA

Template:ABSTRACT PUBMED 24617852

Function

[DPOLX_ASFB7] Error-prone polymerase lacking a proofreading 3'-5' exonuclease which plays a role in viral DNA repair. Specifically binds intermediates in the single-nucleotide base-excision repair process. Also catalyzes DNA polymerization with low nucleotide-insertion fidelity. Together with the viral DNA ligase, fills the single nucleotide gaps generated by the AP endonuclease.[1] [2]

About this Structure

2m2v is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Wu WJ, Su MI, Wu JL, Kumar S, Lim LH, Wang CW, Nelissen FH, Chen MC, Doreleijers JF, Wijmenga SS, Tsai MD. How a Low-Fidelity DNA Polymerase Chooses Non-Watson-Crick from Watson-Crick Incorporation. J Am Chem Soc. 2014 Mar 21. PMID:24617852 doi:http://dx.doi.org/10.1021/ja4102375
  1. ↑ Garcia-Escudero R, Garcia-Diaz M, Salas ML, Blanco L, Salas J. DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA. J Mol Biol. 2003 Mar 7;326(5):1403-12. PMID:12595253
  2. ↑ Showalter AK, Byeon IJ, Su MI, Tsai MD. Solution structure of a viral DNA polymerase X and evidence for a mutagenic function. Nat Struct Biol. 2001 Nov;8(11):942-6. PMID:11685239 doi:10.1038/nsb1101-942

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