2spc
From Proteopedia
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| - | [[Image:2spc.jpg|left|200px]] | + | [[Image:2spc.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN''' | + | {{Structure |
| + | |PDB= 2spc |SIZE=350|CAPTION= <scene name='initialview01'>2spc</scene>, resolution 1.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2SPC is a [ | + | 2SPC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SPC OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the repetitive segments of spectrin., Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton D, Science. 1993 Dec 24;262(5142):2027-30. PMID:[http:// | + | Crystal structure of the repetitive segments of spectrin., Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton D, Science. 1993 Dec 24;262(5142):2027-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8266097 8266097] |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cytoskeleton]] | [[Category: cytoskeleton]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:38:38 2008'' |
Revision as of 16:38, 20 March 2008
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| , resolution 1.8Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN
Overview
The elongated proteins of the spectrin family (dystrophin, alpha-actinin, and spectrin) contain tandemly repeated segments and form resilient cellular meshworks by cross-linking actin filaments. The structure of one of the repetitive segments of alpha-spectrin was determined at a 1.8 angstrom resolution. A segment consists of a three-helix bundle. A model of the interface between two tandem segments suggests that hydrophobic interactions between segments may constrain intersegment flexibility. The helix side chain interactions explain how mutations that are known to produce hemolytic anemias disrupt spectrin associations that sustain the integrity of the erythrocyte membrane.
About this Structure
2SPC is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Crystal structure of the repetitive segments of spectrin., Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton D, Science. 1993 Dec 24;262(5142):2027-30. PMID:8266097
Page seeded by OCA on Thu Mar 20 18:38:38 2008
