2m9v

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{{STRUCTURE_2m9v| PDB=2m9v | SCENE= }}
{{STRUCTURE_2m9v| PDB=2m9v | SCENE= }}
===Structure of Saccharomyces cerevisiae Est3 protein===
===Structure of Saccharomyces cerevisiae Est3 protein===
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{{ABSTRACT_PUBMED_24344315}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
+
<ref group="xtra">PMID:024344315</ref><references group="xtra"/><references/>
[[Category: Armstrong, G S.]]
[[Category: Armstrong, G S.]]
[[Category: Rao, T.]]
[[Category: Rao, T.]]
[[Category: Wuttke, D S.]]
[[Category: Wuttke, D S.]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 07:14, 15 January 2014

Template:STRUCTURE 2m9v

Contents

Structure of Saccharomyces cerevisiae Est3 protein

Template:ABSTRACT PUBMED 24344315

Function

[EST3_YEAST] Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.[1] [2] [3] [4] [5] [6]

About this Structure

2m9v is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Rao T, Lubin JW, Armstrong GS, Tucey TM, Lundblad V, Wuttke DS. Structure of Est3 reveals a bimodal surface with differential roles in telomere replication. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):214-8. doi: 10.1073/pnas.1316453111. , Epub 2013 Dec 16. PMID:24344315 doi:http://dx.doi.org/10.1073/pnas.1316453111
  1. ↑ Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics. 1996 Dec;144(4):1399-412. PMID:8978029
  2. ↑ Morris DK, Lundblad V. Programmed translational frameshifting in a gene required for yeast telomere replication. Curr Biol. 1997 Dec 1;7(12):969-76. PMID:9382847
  3. ↑ Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11190-5. PMID:9326584
  4. ↑ Diede SJ, Gottschling DE. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell. 1999 Dec 23;99(7):723-33. PMID:10619426
  5. ↑ Sharanov YS, Zvereva MI, Dontsova OA. Saccharomyces cerevisiae telomerase subunit Est3p binds DNA and RNA and stimulates unwinding of RNA/DNA heteroduplexes. FEBS Lett. 2006 Aug 21;580(19):4683-90. Epub 2006 Jul 24. PMID:16884717 doi:http://dx.doi.org/10.1016/j.febslet.2006.07.048
  6. ↑ Yang CP, Chen YB, Meng FL, Zhou JQ. Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Res. 2006 Jan 17;34(2):407-16. Print 2006. PMID:16418502 doi:http://dx.doi.org/10.1093/nar/gkj445

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