4ft8

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{{STRUCTURE_4ft8| PDB=4ft8 | SCENE= }}
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==E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands==
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===E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands===
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<StructureSection load='4ft8' size='340' side='right' caption='[[4ft8]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4ft8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FT8 OCA]. <br>
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[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3357, cap, crp, csm, JW5702 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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==About this Structure==
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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[[4ft8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FT8 OCA].
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ft8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ft8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ft8 PDBsum]</span></td></tr>
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<table>
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==Reference==
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== References ==
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<references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ecoli]]
[[Category: Lawson, C L.]]
[[Category: Lawson, C L.]]
[[Category: Rao, R.]]
[[Category: Rao, R.]]

Revision as of 07:02, 7 May 2014

E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands

4ft8, resolution 1.97Å

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