Stimulator of interferon genes (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling.
3D structures of STING
4ef5, 4f5w, 4f9e – hSTING CTD - human
4f5e – hSTING CTD (mutant)
4jc5, 4kc0 – mSTING CTD - mouse
STING complex with ligand
4ef4, 4f5y, 4f9g – hSTING CTD + c-di-GMP
4emt – hSTING residues 155-341 + c-di-GMP
4f5d – hSTING CTD (mutant) + c-di-GMP
4kby – mSTING CTD + c-di-GMP
4ksy – hSTING CTD + cGAMP
4loh, 4loi – hSTING CTD + c-di-GMP derivative
4loj, 4lok – mSTING CTD + c-di-GMP derivative
4lol – mSTING CTD + chemptherapeutic agent DMXAA
