Ire1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='3lj0' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with cyclin-dependent kinase inhibitor (PDB entry [[3lj1]])' scene=''> |
| - | '''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation. | + | '''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:w23880584</ref>. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation. |
==3D structures of Ire1== | ==3D structures of Ire1== | ||
| Line 12: | Line 12: | ||
[[3lj1]], [[3lj2]] - yIre1 cytoplasmic domain + inhibitor<br /> | [[3lj1]], [[3lj2]] - yIre1 cytoplasmic domain + inhibitor<br /> | ||
[[3p23]] - hIre1 cytoplasmic domain + ADP | [[3p23]] - hIre1 cytoplasmic domain + ADP | ||
| + | |||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:35, 31 March 2016
| |||||||||||
