3rnk

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{{STRUCTURE_3rnk| PDB=3rnk | SCENE= }}
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==Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain==
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===Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain===
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<StructureSection load='3rnk' size='340' side='right' caption='[[3rnk]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3rnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNK FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1npu|1npu]], [[3bov|3bov]], [[3bp5|3bp5]], [[3bp6|3bp6]], [[3rnq|3rnq]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pd1, Pdcd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B7dc, Btdc, Cd273, Murine, Pdcd1lg2, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnk RCSB], [http://www.ebi.ac.uk/pdbsum/3rnk PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>
[[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>
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==About this Structure==
 
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[[3rnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNK OCA].
 
==See Also==
==See Also==
*[[Cell death protein|Cell death protein]]
*[[Cell death protein|Cell death protein]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
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[[Category: Almo, S C.]]
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[[Category: Almo, S C]]
[[Category: Cao, E]]
[[Category: Cao, E]]
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[[Category: Lazar-Molnar, E.]]
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[[Category: Lazar-Molnar, E]]
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[[Category: Nathenson, S G.]]
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[[Category: Nathenson, S G]]
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[[Category: Ramagopal, U A.]]
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[[Category: Ramagopal, U A]]
[[Category: B7-dc]]
[[Category: B7-dc]]
[[Category: Complex]]
[[Category: Complex]]

Revision as of 07:56, 25 December 2014

Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain

3rnk, resolution 1.74Å

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