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4lv4

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4lv4| PDB=4lv4 | SCENE= }}
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===A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase===
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{{ABSTRACT_PUBMED_24325645}}
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The entry 4lv4 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ALF_MYCTU ALF_MYCTU]] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).
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Authors: Capodagli, G.C., Pegan, S.D.
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==About this Structure==
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[[4lv4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV4 OCA].
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Description: A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase
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==Reference==
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<ref group="xtra">PMID:024325645</ref><references group="xtra"/><references/>
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[[Category: Fructose-bisphosphate aldolase]]
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[[Category: Capodagli, G C.]]
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[[Category: Pegan, S D.]]
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[[Category: 6-bisphosphate aldolase]]
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[[Category: 8-hydroxyquinoline-2-carboxylic acid]]
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[[Category: Aldol condensation]]
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[[Category: Class ii fructose-1]]
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[[Category: Dihydroxyacetone]]
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[[Category: Glyceraldehyde-3-phosphate]]
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[[Category: Glycolysis]]
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[[Category: Lyase]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Metal-binding]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Zinc enzyme]]

Revision as of 10:32, 8 January 2014

Template:STRUCTURE 4lv4

Contents

A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase

Template:ABSTRACT PUBMED 24325645

Function

[ALF_MYCTU] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).

About this Structure

4lv4 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Capodagli GC, Sedhom WG, Jackson M, Ahrendt KA, Pegan SD. A Noncompetitive Inhibitor for Mycobacterium tuberculosis's Class IIa Fructose 1,6-Bisphosphate Aldolase. Biochemistry. 2013 Dec 24. PMID:24325645 doi:http://dx.doi.org/10.1021/bi401022b

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OCA

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