4ncr

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'''Unreleased structure'''
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{{STRUCTURE_4ncr| PDB=4ncr | SCENE= }}
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===Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169===
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{{ABSTRACT_PUBMED_24500695}}
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The entry 4ncr is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
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Authors: Neres, J., Pojer, F., Cole, S.T.
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==About this Structure==
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[[4ncr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCR OCA].
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Description: Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169
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==Reference==
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<ref group="xtra">PMID:024500695</ref><references group="xtra"/><references/>
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[[Category: Cole, S T.]]
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[[Category: Neres, J.]]
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[[Category: Pojer, F.]]
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[[Category: Decaprenylphosphoryl-beta-d-ribose oxidase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 17:23, 19 February 2014

Template:STRUCTURE 4ncr

Contents

Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169

Template:ABSTRACT PUBMED 24500695

Function

[DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).[1]

About this Structure

4ncr is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Makarov V, Lechartier B, Zhang M, Neres J, van der Sar AM, Raadsen SA, Hartkoorn RC, Ryabova OB, Vocat A, Decosterd LA, Widmer N, Buclin T, Bitter W, Andries K, Pojer F, Dyson PJ, Cole ST. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med. 2014 Feb 5. PMID:24500695 doi:http://dx.doi.org/10.1002/emmm.201303575
  1. ↑ Mikusova K, Huang H, Yagi T, Holsters M, Vereecke D, D'Haeze W, Scherman MS, Brennan PJ, McNeil MR, Crick DC. Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose. J Bacteriol. 2005 Dec;187(23):8020-5. PMID:16291675 doi:http://dx.doi.org/10.1128/JB.187.23.8020-8025.2005

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OCA

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