2v0f

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[[Image:2v0f.gif|left|200px]]<br /><applet load="2v0f" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2v0f.gif|left|200px]]
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caption="2v0f" />
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'''BRK DOMAIN FROM HUMAN CHD7'''<br />
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{{Structure
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|PDB= 2v0f |SIZE=350|CAPTION= <scene name='initialview01'>2v0f</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''BRK DOMAIN FROM HUMAN CHD7'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2V0F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0F OCA].
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2V0F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0F OCA].
==Reference==
==Reference==
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Solution structure of the BRK domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17603073 17603073]
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Solution structure of the BRK domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17603073 17603073]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transcription regulation]]
[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:52:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:41:54 2008''

Revision as of 16:41, 20 March 2008

Image:2v0f.gif


PDB ID 2v0f

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Coordinates: save as pdb, mmCIF, xml



BRK DOMAIN FROM HUMAN CHD7


Contents

Overview

CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.

Disease

Known diseases associated with this structure: CHARGE syndrome OMIM:[608892], Scoliosis, idiopathic 3 OMIM:[608892]

About this Structure

2V0F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the BRK domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:17603073

Page seeded by OCA on Thu Mar 20 18:41:54 2008

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