2v1y

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[[Image:2v1y.gif|left|200px]]<br /><applet load="2v1y" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2v1y.gif|left|200px]]
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caption="2v1y, resolution 2.40&Aring;" />
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'''STRUCTURE OF A PHOSPHOINOSITIDE 3-KINASE ALPHA ADAPTOR-BINDING DOMAIN (ABD) IN A COMPLEX WITH THE ISH2 DOMAIN FROM P85 ALPHA'''<br />
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{{Structure
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|PDB= 2v1y |SIZE=350|CAPTION= <scene name='initialview01'>2v1y</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153]
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|GENE=
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}}
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'''STRUCTURE OF A PHOSPHOINOSITIDE 3-KINASE ALPHA ADAPTOR-BINDING DOMAIN (ABD) IN A COMPLEX WITH THE ISH2 DOMAIN FROM P85 ALPHA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2V1Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1Y OCA].
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2V1Y is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1Y OCA].
==Reference==
==Reference==
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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit., Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL, Science. 2007 Jul 13;317(5835):239-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17626883 17626883]
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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit., Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL, Science. 2007 Jul 13;317(5835):239-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17626883 17626883]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: host-virus interaction]]
[[Category: host-virus interaction]]
[[Category: kinase]]
[[Category: kinase]]
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[[Category: oncogenic mutations]]
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[[Category: oncogenic mutation]]
[[Category: phosphoinositide]]
[[Category: phosphoinositide]]
[[Category: phosphoinositide 3-kinase]]
[[Category: phosphoinositide 3-kinase]]
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:52:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:42:27 2008''

Revision as of 16:42, 20 March 2008

Image:2v1y.gif


PDB ID 2v1y

Drag the structure with the mouse to rotate
, resolution 2.40Å
Activity: Phosphatidylinositol-4,5-bisphosphate 3-kinase, with EC number 2.7.1.153
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF A PHOSPHOINOSITIDE 3-KINASE ALPHA ADAPTOR-BINDING DOMAIN (ABD) IN A COMPLEX WITH THE ISH2 DOMAIN FROM P85 ALPHA


Overview

Many human cancers involve up-regulation of the phosphoinositide 3-kinase PI3Kalpha, with oncogenic mutations identified in both the p110alpha catalytic and the p85alpha regulatory subunits. We used crystallographic and biochemical approaches to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains. A structure of the adaptor-binding domain of p110alpha in a complex with the p85alpha inter-Src homology 2 (inter-SH2) domain shows that oncogenic mutations in the adaptor-binding domain are not at the inter-SH2 interface but in a polar surface patch that is a plausible docking site for other domains in the holo p110/p85 complex. We also examined helical domain mutations and found that the Glu545 to Lys545 (E545K) oncogenic mutant disrupts an inhibitory charge-charge interaction with the p85 N-terminal SH2 domain. These studies extend our understanding of the architecture of PI3Ks and provide insight into how two classes of mutations that cause a gain in function can lead to cancer.

About this Structure

2V1Y is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit., Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL, Science. 2007 Jul 13;317(5835):239-42. PMID:17626883

Page seeded by OCA on Thu Mar 20 18:42:27 2008

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