4npq
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4npq| PDB=4npq | SCENE= }} | {{STRUCTURE_4npq| PDB=4npq | SCENE= }} | ||
===The resting-state conformation of the GLIC ligand-gated ion channel=== | ===The resting-state conformation of the GLIC ligand-gated ion channel=== | ||
| + | {{ABSTRACT_PUBMED_24367074}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024367074</ref><references group="xtra"/><references/> |
[[Category: Changeux, J P.]] | [[Category: Changeux, J P.]] | ||
[[Category: Corringer, P J.]] | [[Category: Corringer, P J.]] | ||
Revision as of 09:13, 5 February 2014
Contents |
The resting-state conformation of the GLIC ligand-gated ion channel
Template:ABSTRACT PUBMED 24367074
Function
[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]
About this Structure
4npq is a 20 chain structure. Full crystallographic information is available from OCA.
Reference
- Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz A, Haouz A, Changeux JP, Corringer PJ, Delarue M. Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi:, 10.1073/pnas.1314997111. Epub 2013 Dec 23. PMID:24367074 doi:http://dx.doi.org/10.1073/pnas.1314997111
- ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371
