4nr8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4nr8| PDB=4nr8 | SCENE= }}
+
==Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand==
-
===Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand===
+
<StructureSection load='4nr8' size='340' side='right' caption='[[4nr8]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Disease==
+
<table><tr><td colspan='2'>[[4nr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NR8 FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LL:5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE'>2LL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nr8 RCSB], [http://www.ebi.ac.uk/pdbsum/4nr8 PDBsum]</span></td></tr>
 +
</table>
 +
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-
 
+
== Function ==
-
==Function==
+
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[4nr8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NR8 OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Human]]
-
<references group="xtra"/><references/>
+
[[Category: Arrowsmith, C H]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Bountra, C]]
-
[[Category: Bountra, C.]]
+
[[Category: Brennan, P]]
-
[[Category: Brennan, P.]]
+
[[Category: Delft, F Von]]
-
[[Category: Delft, F Von.]]
+
[[Category: Edwards, A M]]
-
[[Category: Edwards, A M.]]
+
[[Category: Fedorov, O]]
-
[[Category: Fedorov, O.]]
+
[[Category: Felletar, I]]
-
[[Category: Felletar, I.]]
+
[[Category: Filippakopoulos, P]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Hay, D]]
-
[[Category: Hay, D.]]
+
[[Category: Knapp, S]]
-
[[Category: Knapp, S.]]
+
[[Category: Martin, S]]
-
[[Category: Martin, S.]]
+
[[Category: Picaud, S]]
-
[[Category: Picaud, S.]]
+
[[Category: Structural genomic]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Chemical tool]]
[[Category: Chemical tool]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Small molecule inhibitor]]
[[Category: Small molecule inhibitor]]
-
[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription-inhibitor complex]]
[[Category: Transcription-inhibitor complex]]

Revision as of 17:08, 21 December 2014

Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand

4nr8, resolution 1.64Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4nr8"
Personal tools