Pantothenate synthetase
From Proteopedia
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==3D structures of pantothenate synthetase== | ==3D structures of pantothenate synthetase== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1iho]] – EcPS – ''Escherichia coli''<br /> | [[1iho]] – EcPS – ''Escherichia coli''<br /> | ||
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===PS binary complex with inhibitor=== | ===PS binary complex with inhibitor=== | ||
| - | [[3cow]], [[3coy]], [[3coz]], [[3imc]], [[3ime]], [[3img]], [[3iub]], [[3iue]], [[3ivc]], [[3ivg]], [[3ivx]], [[3isj]], [[3le8]] - MtPS (mutant) + inhibitor | + | [[3cow]], [[3coy]], [[3coz]], [[3imc]], [[3ime]], [[3img]], [[3iub]], [[3iue]], [[3ivc]], [[3ivg]], [[3ivx]], [[3isj]], [[3le8]], [[4ddh]], [[4ddk]], [[4ddm]], [[4de5]], [[4ef6]], [[4efk]], [[4fzj]], [[4g5f]] - MtPS (mutant) + inhibitor |
===PS ternary complex=== | ===PS ternary complex=== | ||
[[2a86]] - MtPS (mutant) + β-alanine + AMP<br /> | [[2a86]] - MtPS (mutant) + β-alanine + AMP<br /> | ||
| + | [[4g5y]] - MtPS (mutant) + thiophene derivative + ATP<br /> | ||
[[3uy4]] - CjPS + pantothenate + AMP<br /> | [[3uy4]] - CjPS + pantothenate + AMP<br /> | ||
[[3qtt]] - FtPS + β-alanine + ATP derivative<br /> | [[3qtt]] - FtPS + β-alanine + ATP derivative<br /> | ||
Revision as of 06:21, 2 April 2014
Pantothenate synthetase (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target.
Contents |
3D structures of pantothenate synthetase
Updated on 02-April-2014
1iho – EcPS – Escherichia coli
1mop, 2a88, 3cov – MtPS (mutant) – Mycobacterium tuberculosis
1ufv - TtPS (mutant) – Thermus thermophilus
1v8f - TtPS
2ejc - PS – Thermotoga maritima
3mue - PS – Salmonella typhimurium
3mxt - CjPS – Campylobacter jejuni
3ag5 - SaPS – Staphylococcus aureus
PS binary complex with adenosine derivatives
1n2g - MtPS + AMPCPP
2a7x - MtPS (mutant) + AMP
3n8h - FtPS + AMP – Francisella tularensis
3q10 - YpPS + AMP – Yersinia pestis
3uk2 - PS + AMP – Burkholderia thailandesis
2a84 - MtPS (mutant) + ATP
2x3f - SaPS + ATP derivative
3inn - PS + ATP – Brucella melitensis
3iob, 3ioc, 3iod, 3ioe - MtPS (mutant) + adenosine derivative
PS binary complex with pantoate derivatives
1n2i - MtPS (mutant) + pantoyl adenylate
1n2j - MtPS (mutant) + pantoate
1n2o - MtPS (mutant) + β-alanine
3q12 - YpPS + pantoate
3ag6 - SaPS + pantoyl adenylate
3guz - EcPS (mutant) + pantoate
PS binary complex with inhibitor
3cow, 3coy, 3coz, 3imc, 3ime, 3img, 3iub, 3iue, 3ivc, 3ivg, 3ivx, 3isj, 3le8, 4ddh, 4ddk, 4ddm, 4de5, 4ef6, 4efk, 4fzj, 4g5f - MtPS (mutant) + inhibitor
PS ternary complex
2a86 - MtPS (mutant) + β-alanine + AMP
4g5y - MtPS (mutant) + thiophene derivative + ATP
3uy4 - CjPS + pantothenate + AMP
3qtt - FtPS + β-alanine + ATP derivative
1n2b, 1n2e – MtPS + pantoate + AMPCPP
