2kzg

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{{STRUCTURE_2kzg| PDB=2kzg | SCENE= }}
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==A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution==
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===A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution===
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<StructureSection load='2kzg' size='340' side='right' caption='[[2kzg]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_20829478}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZG FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uzc|1uzc]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HYPA, FBP11, PRPF40A, FLAF1, FNBP3, HIP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzg RCSB], [http://www.ebi.ac.uk/pdbsum/2kzg PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kzg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Proteins can sample conformational states that are critical for function but are seldom detected directly because of their low occupancies and short lifetimes. In this work, we used chemical shifts and bond-vector orientation constraints obtained from nuclear magnetic resonance relaxation dispersion spectroscopy, in concert with a chemical shift-based method for structure elucidation, to determine an atomic-resolution structure of an "invisible" folding intermediate of a small protein module: the FF domain. The structure reveals non-native elements preventing formation of the native conformation in the carboxyl-terminal part of the protein. This is consistent with the kinetics of folding in which a well-structured intermediate forms rapidly and then rearranges slowly to the native state. The approach introduces a general strategy for structure determination of low-populated and transiently formed protein states.
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==Function==
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A transient and low-populated protein-folding intermediate at atomic resolution.,Korzhnev DM, Religa TL, Banachewicz W, Fersht AR, Kay LE Science. 2010 Sep 10;329(5997):1312-6. PMID:20829478<ref>PMID:20829478</ref>
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[[http://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN]] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[2kzg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZG OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020829478</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Banachewicz, W.]]
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</StructureSection>
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[[Category: Fersht, A R.]]
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[[Category: Human]]
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[[Category: Kay, L E.]]
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[[Category: Banachewicz, W]]
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[[Category: Korzhnev, D M.]]
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[[Category: Fersht, A R]]
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[[Category: Religa, T L.]]
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[[Category: Kay, L E]]
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[[Category: Korzhnev, D M]]
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[[Category: Religa, T L]]
[[Category: Cpmg]]
[[Category: Cpmg]]
[[Category: Folding intermediate]]
[[Category: Folding intermediate]]

Revision as of 16:16, 21 December 2014

A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution

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