Signal recognition particle receptor

From Proteopedia

Revision as of 08:12, 8 May 2014

Signal recognition particle receptor (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the signal recognition particle (SRP). SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called FtsY.

3D structures of SRPR

Updated on 08-May-2014

1nrj – ySRPR α+β subunits + GTP – yeast
2fh5 - hSRPR α+β subunits + GTP – human
2ged - ySRPR β subunit (mutant)
2go5 - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - EM
3dm9, 3dmd, 3e70 – SRPR + GDP – Pyrococcus furiosus

SRPR FtsY

1zu5, 1zu4 – SRPR FtsY NG domain – Mycoplasma mycoides
1vma – SRPR FtsY – Thermotoga maritima
2yhs, 2qy9, 1fts – EcSRPR FtsY NG domain – Escherichia coli
2q9a – EcSRPR FtsY
2q9c, 2q9b – EcSRPR FtsY NG domain + GMPPNP
2iyl – EcSRPR FtsY residues 20-303 + GDP
2xxa - EcSRPR FtsY NG domain + signal recognition particle protein residues 1-433 (mutant) + 4.5SRNA
3zn8 - EcSRPR FtsY NG domain + signal recognition particle protein 54 NG domain + 4.5SRNA + dipeptidyl aminopeptidase B
2j7p, 1rj9, 1okk – TaSRPR FtsY NG domain + signal recognition particle protein – Thermus aquaticus
2cnw – TaSRPR FtsY NG domain + signal recognition particle protein + GDP
4c7o – EcFtsY + EcSRP + SRP RNA
2xkv – EcFtsY + EcSRP NG+M domains + 4.5S RNA