2v9v

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[[Image:2v9v.jpg|left|200px]]<br /><applet load="2v9v" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2v9v.jpg|left|200px]]
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caption="2v9v, resolution 1.10&Aring;" />
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'''CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)'''<br />
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{{Structure
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|PDB= 2v9v |SIZE=350|CAPTION= <scene name='initialview01'>2v9v</scene>, resolution 1.10&Aring;
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2V9V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9V OCA].
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2V9V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9V OCA].
==Reference==
==Reference==
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Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB., Ganichkin O, Wahl MC, Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1075-81. Epub 2007, Sep 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17881825 17881825]
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Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB., Ganichkin O, Wahl MC, Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1075-81. Epub 2007, Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17881825 17881825]
[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein biosynthesis]]
[[Category: protein biosynthesis]]
[[Category: protein conformational change]]
[[Category: protein conformational change]]
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[[Category: protein dynamics]]
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[[Category: protein dynamic]]
[[Category: selenocysteine]]
[[Category: selenocysteine]]
[[Category: selenoprotein biosynthesis]]
[[Category: selenoprotein biosynthesis]]
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[[Category: winged-helix domain]]
[[Category: winged-helix domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:54:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:44:44 2008''

Revision as of 16:44, 20 March 2008

Image:2v9v.jpg


PDB ID 2v9v

Drag the structure with the mouse to rotate
, resolution 1.10Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF MOORELLA THERMOACETICA SELB(377-511)


Overview

The crystal structure of the first two winged-helix motifs of translation elongation factor SelB from Moorella thermoacetica has been determined at 1.1 A resolution. Compared with the previous structure of the two domains in conjunction with winged-helix modules 3 and 4, the first winged-helix domain underwent a substantial conformational change during which the alpha-helical and beta-sheet portions of the element opened up like a shell. This conformational rearrangement was elicited by a change in the orientation of Trp396, leading to the disclosure of a bona fide ligand-binding site in the direct vicinity of Trp396. Additionally, the C-terminal tail of the second domain followed a different path compared with the previous structure. It is conceivable that these conformational switches constitute part of the molecular mechanism that underlies the communication between the N-terminal part of SelB, which binds Sec-tRNA(Sec) and GTP, and the C-terminal part of the protein, which binds selenocysteine-insertion sequences.

About this Structure

2V9V is a Single protein structure of sequence from Moorella thermoacetica. Full crystallographic information is available from OCA.

Reference

Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB., Ganichkin O, Wahl MC, Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1075-81. Epub 2007, Sep 19. PMID:17881825

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