2vb3

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[[Image:2vb3.jpg|left|200px]]<br /><applet load="2vb3" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2vb3.jpg|left|200px]]
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caption="2vb3, resolution 2.33&Aring;" />
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'''CRYSTAL STRUCTURE OF AG(I)CUSF'''<br />
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{{Structure
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|PDB= 2vb3 |SIZE=350|CAPTION= <scene name='initialview01'>2vb3</scene>, resolution 2.33&Aring;
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|SITE= <scene name='pdbsite=AC1:Ag+Binding+Site+For+Chain+X'>AC1</scene>
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|LIGAND= <scene name='pdbligand=AG:SILVER ION'>AG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF AG(I)CUSF'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2VB3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=AG:'>AG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ag+Binding+Site+For+Chain+X'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB3 OCA].
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2VB3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB3 OCA].
==Reference==
==Reference==
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Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18157124 18157124]
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Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18157124 18157124]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: periplasm]]
[[Category: periplasm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:54:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:04 2008''

Revision as of 16:45, 20 March 2008

Image:2vb3.jpg


PDB ID 2vb3

Drag the structure with the mouse to rotate
, resolution 2.33Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF AG(I)CUSF


Overview

Methionine-rich motifs have an important role in copper trafficking factors, including the CusF protein. Here we show that CusF uses a new metal recognition site wherein Cu(I) is tetragonally displaced from a Met2His ligand plane toward a conserved tryptophan. Spectroscopic studies demonstrate that both thioether ligation and strong cation-pi interactions with tryptophan stabilize metal binding. This novel active site chemistry affords mechanisms for control of adventitious metal redox and substitution chemistry.

About this Structure

2VB3 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:18157124

Page seeded by OCA on Thu Mar 20 18:45:04 2008

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