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4cjy

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m (Protected "4cjy" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4cjy| PDB=4cjy | SCENE= }}
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===Crystal structure of the human CDK12-cyclinK complex===
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The entry 4cjy is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.
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Authors: Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Chaikuad, A., Goubin, S., Krojer, T., Sorrell, F.J., Nowak, R., Williams, E., Kopec, J., Mahajan, R.P., Burgess-Brown, N., Carpenter, E.P., Knapp, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
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==Function==
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[[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref> [[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>
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Description: Crystal structure of the human CDK12-cyclinK complex
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==About this Structure==
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[[4cjy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CJY OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Cyclin-dependent kinase]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Bullock, A.]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Carpenter, E P.]]
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[[Category: Chaikuad, A.]]
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[[Category: Clarke, S E.Dixon.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Elkins, J M.]]
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[[Category: Goubin, S.]]
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[[Category: Knapp, S.]]
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[[Category: Kopec, J.]]
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[[Category: Krojer, T.]]
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[[Category: Mahajan, R P.]]
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[[Category: Nowak, R.]]
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[[Category: Pike, A C.W.]]
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[[Category: Sorrell, F J.]]
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[[Category: Williams, E.]]
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[[Category: Kinase]]
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[[Category: Transferase]]

Revision as of 08:21, 15 January 2014

Template:STRUCTURE 4cjy

Contents

Crystal structure of the human CDK12-cyclinK complex

Disease

[CDK12_HUMAN] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

Function

[CCNK_HUMAN] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).[1] [CDK12_HUMAN] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.[2] [3] [4]

About this Structure

4cjy is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Fu TJ, Peng J, Lee G, Price DH, Flores O. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem. 1999 Dec 3;274(49):34527-30. PMID:10574912
  2. ↑ Ko TK, Kelly E, Pines J. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J Cell Sci. 2001 Jul;114(Pt 14):2591-603. PMID:11683387
  3. ↑ Iorns E, Martens-de Kemp SR, Lord CJ, Ashworth A. CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Carcinogenesis. 2009 Oct;30(10):1696-701. doi: 10.1093/carcin/bgp187. Epub 2009, Aug 3. PMID:19651820 doi:http://dx.doi.org/10.1093/carcin/bgp187
  4. ↑ Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 2010 Oct 15;24(20):2303-16. doi: 10.1101/gad.1968210. PMID:20952539 doi:http://dx.doi.org/10.1101/gad.1968210

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