4j14

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'''Unreleased structure'''
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{{STRUCTURE_4j14| PDB=4j14 | SCENE= }}
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===Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound===
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{{ABSTRACT_PUBMED_23604141}}
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The entry 4j14 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
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Authors: Stout, C.D., Mast, N., Pikuleva, I.A.
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==About this Structure==
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[[4j14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J14 OCA].
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Description: Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
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==Reference==
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<ref group="xtra">PMID:023604141</ref><references group="xtra"/><references/>
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[[Category: Cholesterol 24-hydroxylase]]
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[[Category: Mast, N.]]
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[[Category: Pikuleva, I A.]]
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[[Category: Stout, C D.]]
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[[Category: Cholesterol 24-hydroxylase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]
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[[Category: Posaconazole]]

Revision as of 08:09, 15 January 2014

Template:STRUCTURE 4j14

Contents

Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound

Template:ABSTRACT PUBMED 23604141

Function

[CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.

About this Structure

4j14 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mast N, Zheng W, Stout CD, Pikuleva IA. Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Mol Pharmacol. 2013 Jul;84(1):86-94. doi: 10.1124/mol.113.085902. Epub 2013 Apr, 19. PMID:23604141 doi:http://dx.doi.org/10.1124/mol.113.085902

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