3zfx
From Proteopedia
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{{STRUCTURE_3zfx| PDB=3zfx | SCENE= }} | {{STRUCTURE_3zfx| PDB=3zfx | SCENE= }} | ||
===Crystal structure of EphB1=== | ===Crystal structure of EphB1=== | ||
| + | {{ABSTRACT_PUBMED_24677421}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[3zfx]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFX OCA]. | [[3zfx]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFX OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Ephrin receptor|Ephrin receptor]] | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024677421</ref><references group="xtra"/><references/> |
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Attwood, T K.]] | [[Category: Attwood, T K.]] | ||
Revision as of 05:25, 9 April 2014
Contents |
Crystal structure of EphB1
Template:ABSTRACT PUBMED 24677421
Function
[EPHB1_HUMAN] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.[1] [2] [3] [4] [5]
About this Structure
3zfx is a 9 chain structure. Full crystallographic information is available from OCA.
See Also
Reference
- Overman RC, Debreczeni JE, Truman CM, McAlister MS, Attwood TK. Completing the structural family portrait of the human EphB tyrosine kinase domains. Protein Sci. 2014 Feb 15. doi: 10.1002/pro.2445. PMID:24677421 doi:http://dx.doi.org/10.1002/pro.2445
- ↑ Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J Biol Chem. 1998 Jan 16;273(3):1303-8. PMID:9430661
- ↑ Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev. 1998 Mar 1;12(5):667-78. PMID:9499402
- ↑ Han DC, Shen TL, Miao H, Wang B, Guan JL. EphB1 associates with Grb7 and regulates cell migration. J Biol Chem. 2002 Nov 22;277(47):45655-61. Epub 2002 Sep 9. PMID:12223469 doi:10.1074/jbc.M203165200
- ↑ Vindis C, Cerretti DP, Daniel TO, Huynh-Do U. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol. 2003 Aug 18;162(4):661-71. PMID:12925710 doi:http://dx.doi.org/10.1083/jcb.200302073
- ↑ Fasen K, Cerretti DP, Huynh-Do U. Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. Traffic. 2008 Feb;9(2):251-66. Epub 2007 Dec 19. PMID:18034775 doi:http://dx.doi.org/10.1111/j.1600-0854.2007.00679.x
